Noble E P, Berman S M, Ozkaragoz T Z, Ritchie T
Alcohol Research Center, University of California, Los Angeles 90024-1759.
Am J Hum Genet. 1994 Apr;54(4):658-68.
Previous studies have indicated the presence of a hereditary component in the generation of the P300, or P3, a late positive component of the event-related potential. Moreover, the dopaminergic system has been implicated in the P3. In the present study, 98 healthy Caucasian boys, mean age of 12.5 years and of above-average intelligence, were studied. The sample was composed of 32 sons of active alcoholic (SAA) fathers, 36 sons of recovering alcoholic (SRA) fathers, and 30 sons of social drinker (SSD) fathers, with none of them having yet begun to consume alcohol or other drugs. TaqI A D2 dopamine receptor alleles (A1 and A2) were determined. A significant difference in the frequency of the A1 allele was found among these three groups of boys, with the SAA group having the highest A1 allele frequency (.313), followed by the SRA (.139) and the SSD (.133) groups. The relationship of the A1 and A2 alleles to P3 amplitude and latency was also determined. The results showed no significant difference in P3 amplitude between boys with the A1 and A2 allele. However, P3 latency was significantly longer in the total sample of boys with the A1 allele compared with those carrying the A2 allele. These findings suggest that polymorphism of the D2 dopamine receptor gene is an important determinant of P3 latency.
先前的研究表明，在事件相关电位的晚期正波成分即P300或P3的产生过程中存在遗传因素。此外，多巴胺能系统也与P3有关。在本研究中，对98名健康的白人男孩进行了研究，他们的平均年龄为12.5岁，智力高于平均水平。样本包括32名父亲为现患酒精依赖者（SAA）的儿子、36名父亲为康复期酒精依赖者（SRA）的儿子和30名父亲为社交饮酒者（SSD）的儿子，他们均未开始饮酒或使用其他药物。测定了TaqI A D2多巴胺受体等位基因（A1和A2）。在这三组男孩中发现A1等位基因频率存在显著差异，SAA组的A1等位基因频率最高（.313），其次是SRA组（.139）和SSD组（.133）。还确定了A1和A2等位基因与P3波幅和潜伏期的关系。结果显示，携带A1和A2等位基因的男孩之间P3波幅无显著差异。然而，与携带A2等位基因的男孩相比，携带A1等位基因的男孩总样本中P3潜伏期显著更长。这些发现表明，D2多巴胺受体基因多态性是P3潜伏期的重要决定因素。
