Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Analytical Chemistry, Faculty of Pharmacy, Mersin University, Mersin, Turkey.
Int J Environ Health Res. 2024 Jan;34(1):90-102. doi: 10.1080/09603123.2022.2131743. Epub 2022 Oct 6.
Owing to the importance of drug delivery, the synthesis of advanced nanomaterials for targeted drug delivery plays a considerable role in medical treatment. One of the most prominent nanomaterials is PIL, which is used as controlled anticancer drug delivery and significantly improves the half-life and antitumor effect. In this study, a stable and effective drug carrier containing silver nanoparticles was reported for the drug delivery with an antimicrobial effect, and the capability of the drug carrier . PILP was synthesized by radical polymerization, and silver nanoparticles were anchored into PIL voids by in-situ reduction, which developed the adsorption antimicrobial effect and capability of the drug carrier. The synthesized nanocomposite was characterized. The Ag-PILP nanocomposite showed antibacterial activityagainst both and with a MIC of 256 μg/mL, and bactericidal activity against and strains with a MBC of 256 and 512 μg/mL, respectively.
由于药物输送的重要性，用于靶向药物输送的先进纳米材料的合成在医学治疗中起着相当大的作用。最突出的纳米材料之一是 PIL，它被用作控制抗癌药物输送，并显著提高了半衰期和抗肿瘤效果。在这项研究中，报道了一种含有银纳米粒子的稳定有效的药物载体，用于具有抗菌作用的药物输送，以及药物载体的能力。PILP 通过自由基聚合合成，银纳米粒子通过原位还原锚定在 PIL 空隙中，从而开发了药物载体的吸附抗菌作用和能力。合成的纳米复合材料进行了表征。Ag-PILP 纳米复合材料对 和 均显示出抗菌活性，MIC 为 256μg/mL，对 和 菌株的杀菌活性分别为 256 和 512μg/mL。
