Hercz P, Várady E, Ungár L, Siklós P, Büky B
Acta Paediatr Hung. 1987;28(1):17-21.
The concentration of steroid and peptide hormones in the development of the respiratory distress syndrome of the newborn has been investigated. Serum progesterone, dehydroandrostenedione sulphate (DHAS) oestradiol, oestriol, cortisol, prolactin and human placental lactogen (HPL) concentrations were measured by radioimmune assay (RIA) in samples obtained from the maternal vein and the premature newborn's umbilical artery and vein. The results were grouped according to gestational age into two groups, 28-32 and 33-36 weeks. Serum cortisol level was lower in maternal blood and both the umbilical vein and artery if the newborn subsequently developed RDS. No deviations from healthy values were encountered with any other hormone. These observations and data in the literature suggest that maturation of the fetal lung is influenced not only by maternal glucocorticoid secretion but also by the activity of the fetal adrenal cortex.
对新生儿呼吸窘迫综合征发育过程中类固醇和肽类激素的浓度进行了研究。通过放射免疫分析法（RIA）测量了从母体静脉以及早产新生儿的脐动脉和脐静脉采集的样本中血清孕酮、硫酸脱氢表雄酮（DHAS）、雌二醇、雌三醇、皮质醇、催乳素和人胎盘催乳素（HPL）的浓度。结果根据胎龄分为两组，28 - 32周和33 - 36周。如果新生儿随后发生呼吸窘迫综合征，母体血液以及脐静脉和脐动脉中的血清皮质醇水平较低。其他任何激素均未出现与健康值的偏差。这些观察结果以及文献中的数据表明，胎儿肺的成熟不仅受母体糖皮质激素分泌的影响，还受胎儿肾上腺皮质活性的影响。
