Kohno H, Furuhashi N, Fukaya T, Tachibana Y, Shinkawa O, Takahashi T, Tanaka M, Suzuki M
Nihon Sanka Fujinka Gakkai Zasshi. 1983 Jul;35(7):891-6.
We measured maternal venous (MV), umbilical arterial (UA) and umbilical venous (UV) cortisol levels of 180 pregnancies at term, and investigated especially cases of fetal distress and neonatal asphyxia. No fetal distress and no neonatal asphyxia cases followed spontaneous vaginal deliveries (94), cesarean sections (18) or breech extractions (6). In cesarean section delivery, the cortisol levels of three individual samples were lower than in other modes of deliveries. The cortisol level of the umbilical artery was significantly higher than that of the umbilical vein in spontaneous vaginal delivery and cesarean section delivery. When spontaneous vaginal deliveries were classified into the fetal distress group and no fetal distress group, the cortisol levels of the umbilical artery and umbilical vein in the former group were significantly higher than those in the latter group. Furthermore, regardless of fetal distress there were significant positive correlations between the cortisol levels of MV & UA, MV & UV, and UA & UV. In addition, as the cortisol level of the maternal vein increased, the umbilical arterial-venous cortisol ratio (UA/UV) gradually approached 1.0. These data suggest that in fetal distress or neonatal asphyxia, the fetus may produce cortisol for itself independent of the mother.
我们测量了180例足月妊娠孕妇的母血静脉（MV）、脐动脉（UA）和脐静脉（UV）皮质醇水平，并特别研究了胎儿窘迫和新生儿窒息的病例。自然阴道分娩（94例）、剖宫产（18例）或臀位牵引术（6例）后均未出现胎儿窘迫和新生儿窒息病例。在剖宫产分娩中，三个个体样本的皮质醇水平低于其他分娩方式。在自然阴道分娩和剖宫产分娩中，脐动脉的皮质醇水平显著高于脐静脉。当自然阴道分娩分为胎儿窘迫组和无胎儿窘迫组时，前一组脐动脉和脐静脉的皮质醇水平显著高于后一组。此外，无论有无胎儿窘迫，MV与UA、MV与UV、UA与UV的皮质醇水平之间均存在显著正相关。此外，随着母血静脉皮质醇水平的升高，脐动脉-静脉皮质醇比值（UA/UV）逐渐接近1.0。这些数据表明，在胎儿窘迫或新生儿窒息时，胎儿可能独立于母亲自身产生皮质醇。
