Xie Jinlu, Li Tao, He Tingting, Xu Rong, Zhang Xianshan, Wang Xuenan, Geng Xiwen
Key Laboratory of Vector Biology and Pathogen Control of Zhejiang Province, School of Medicine, Huzhou University, Huzhou Central Hospital, Huzhou 313000, China.
Key Laboratory of Vector Biology and Pathogen Control of Zhejiang Province, School of Medicine, Huzhou University, Huzhou Central Hospital, Huzhou 313000, China.
Brain Res. 2022 Dec 15;1797:148115. doi: 10.1016/j.brainres.2022.148115. Epub 2022 Oct 3.
Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the progressive degeneration of neurons in the substantia nigra pars compacta. Deep brain stimulation (DBS) is an effective treatment for PD cardinal motor symptoms. DBS of GPe has been recognized as an effective treatment option for motor symptoms of PD, but the mechanism is still essentially unknown. To investigate the impact of DBS in the external segment of globus pallidus (GPe) on the pathway of the basal ganglia (BG), we recorded the electrical activities of single neurons and local field potential (LFP) of the internal segment of globus pallidus (GPi). The results showed that the firing rate of GPi neurons in the 6-OHDA lesioned rats returned to the normal level after GPe-DBS for two weeks. Moreover, the CV value of GPi neurons is significantly lower than that in the PD group. The different frequency bands of GPi LFP in PD rats have improved correspondingly. These findings indicate that the improvement of the electrical activity of GPi by GPe-DBS in PD rats may be an important electrophysiological mechanism for treating PD.
帕金森病（PD）是一种进行性神经退行性疾病，其特征是黑质致密部神经元进行性退化。深部脑刺激（DBS）是治疗PD主要运动症状的有效方法。苍白球外侧部（GPe）的DBS已被认为是治疗PD运动症状的有效选择，但机制仍基本未知。为了研究苍白球外侧部（GPe）的DBS对基底神经节（BG）通路的影响，我们记录了苍白球内侧部（GPi）单个神经元的电活动和局部场电位（LFP）。结果显示，6-OHDA损伤大鼠在GPe-DBS两周后，GPi神经元的放电频率恢复到正常水平。此外，GPi神经元的CV值显著低于PD组。PD大鼠GPi LFP的不同频段也相应得到改善。这些发现表明，GPe-DBS改善PD大鼠GPi的电活动可能是治疗PD的重要电生理机制。
