Department of Endocrine Surgery, General Surgery Service, Virgen de la Arrixaca University Hospital, Murcia, Spain; Biomedical Research Institute of Murcia (IMIB-Arrixaca), Murcia, Spain.
Department of Endocrine Surgery, General Surgery Service, Virgen de la Arrixaca University Hospital, Murcia, Spain; Biomedical Research Institute of Murcia (IMIB-Arrixaca), Murcia, Spain.
Ann Endocrinol (Paris). 2023 Feb;84(1):1-7. doi: 10.1016/j.ando.2022.08.003. Epub 2022 Oct 3.
Quality of life (QoL) in patients with primary hyperparathyroidism (PHPT) can be negatively affected by the disease, and it is important to identify risk factors. The objectives of the present study were to analyze QoL, mood and quality of sleep in patients with PHPT and to determine the impact of socio-personal and clinical variables.
The study group included patients diagnosed with PHPT, and the control group was taken from general population, paired by age and gender. QoL was analyzed using the SF-36 and the PHPQoL questionnaires. The Beck-II and Pittsburg questionnaires were used to assess depression and sleep quality. Socio-personal and clinical variables were analyzed. Statistical analysis on SPSS software v.28 used the Student t-test, ANOVA, Pearson's rank correlation, Mann-Whitney test, Kruskal-Wallis test and Spearman's rank correlation. A multiple linear regression model of the QoL was constructed.
Sixty-five patients with PHPT were analyzed. A greater negative effect on QoL, mood and sleep quality were observed in patients with PHPT than in controls (P<0.05), with a good correlation between the various questionnaires. Several socio-personal variables had an effect on QoL and mood (P<0.05). QoL in patients with PHPT was affected by educational level, having offspring, and psychological symptoms (P<0.05).
Patients with PHPT had poorer QoL and greater neurocognitive disorder than the general population. Socio-personal profile should be taken into account in the clinical assessment of these patients, together with psychological symptoms.
甲状旁腺功能亢进症（PHPT）可对患者的生活质量（QoL）产生负面影响，识别相关风险因素十分重要。本研究旨在分析 PHPT 患者的 QoL、情绪和睡眠质量，并确定社会人口学和临床变量的影响。
研究组纳入 PHPT 患者，对照组为按年龄和性别匹配的一般人群。采用 SF-36 和 PHPQoL 问卷评估 QoL。采用 Beck-II 和 Pittsburg 问卷评估抑郁和睡眠质量。分析社会人口学和临床变量。采用 SPSS 软件 v.28 进行统计学分析，使用学生 t 检验、方差分析、Pearson 秩相关、Mann-Whitney 检验、Kruskal-Wallis 检验和 Spearman 秩相关。构建 QoL 的多元线性回归模型。
共分析了 65 例 PHPT 患者。与对照组相比，PHPT 患者的 QoL、情绪和睡眠质量较差（P<0.05），且各问卷之间具有良好的相关性。一些社会人口学变量对 QoL 和情绪有影响（P<0.05）。PHPT 患者的 QoL 受教育程度、是否有子女和心理症状影响（P<0.05）。
PHPT 患者的 QoL 较一般人群差，神经认知障碍更严重。在对这些患者进行临床评估时，应考虑社会人口学特征，并关注心理症状。
