阿莫西林：在正常受试者、恶性贫血患者及肾衰竭患者中的药代动力学研究。
Amoxycillin: pharmacokinetic studies in normal subjects, patients with pernicious anaemia and those with renal failure.
作者信息
Lawson D H, Henderson A K, McGeachy R R
出版信息
Postgrad Med J. 1974 Aug;50(586):500-3. doi: 10.1136/pgmj.50.586.500.
Abstract
This paper presents data on the absorption and disappearance of a new semisynthetic antibiotic—amoxycillin—in patients with pernicious anaemia and those with renal failure. Absorption of this drug is unimpaired in these patients. Adequate serum and urine levels are obtained even in patients with creatinine clearance levels below 10 ml/min. The half-life of this drug is markedly prolonged in patients undergoing regular dialysis therapy, and a single 250 mg dose will provide adequate serum levels for 24 hr, if this is given after dialysis is complete.
摘要
本文介绍了一种新型半合成抗生素——阿莫西林在恶性贫血患者和肾衰竭患者体内的吸收及消除情况。这些患者对该药的吸收未受影响。即使肌酐清除率低于10毫升/分钟的患者也能达到足够的血清和尿液水平。在接受定期透析治疗的患者中，该药的半衰期明显延长，如果在透析结束后给予单次250毫克剂量，将能在24小时内维持足够的血清水平。
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Postgrad Med J. 1974 Aug;50(586):500-3. doi: 10.1136/pgmj.50.586.500.
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本文引用的文献
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Oral cephalexin and ampicillin: antimicrobial activity, recovery in urine, and persistence in blood of uremic patients.口服头孢氨苄和氨苄西林：尿毒症患者的抗菌活性、尿液中的回收率及血液中的持续时间
Ann Intern Med. 1970 Mar;72(3):349-56. doi: 10.7326/0003-4819-72-3-349.
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Simplified, accurate method for antibiotic assay of clinical specimens.临床标本抗生素检测的简化、准确方法。
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Amoxycillin: a new semi-synthetic penicillin.阿莫西林：一种新型半合成青霉素。
Br Med J. 1972 Jul 1;3(5817):13-6. doi: 10.1136/bmj.3.5817.13.
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