Alharbi Badr, Alnosayan Hatim S, Al-Harbi Faisal Awadh, Alaidah Alwleed M, Almoshiqeh Albaraa Nasser, Alharbi Abdullah Mulfi, Alwashmi Emad, Altwairgi Adil Khalaf
Surgery, College of Medicine, Qassim University, Buraydah, SAU.
Urology, Medical City, Qassim University, Buraydah, SAU.
Cureus. 2024 Oct 31;16(10):e72748. doi: 10.7759/cureus.72748. eCollection 2024 Oct.
Renal cell carcinoma (RCC) is an aggressive malignant neoplasm that accounts for 90% of renal cancers with rising incidence worldwide. This study aimed to analyze the demographics and clinical profiles, histopathological presentations, and treatment outcomes of 73 RCC patients at a hospital in Qassim region, Saudi Arabia.
This retrospective observational study was conducted at King Fahad Specialist Hospital, Buraidah, from October 2017 to July 2024. Census sampling included all patients diagnosed with RCC. Data on demographics, clinical, and histopathological characteristics were analyzed using SPSS version 26 (Armonk, NY: IBM Corp.).
RCC was found to be more prevalent in males and older patients with common comorbidities such as diabetes and hypertension. Among the histopathological types of RCC, clear cell RCC (ccRCC) is most frequently reported in 60.3% of patients, followed by chromophobe RCC (chRCC) and papillary RCC (pRCC), in 16.4% and 11% of patients, respectively. Fuhrman grade 2 stage was seen in 65.8% of the tumors, indicating its moderately aggressive form. Incidental diagnoses accounted for 45.2% of patients, with 93.2% demonstrating no evidence of metastasis at diagnosis. The primary mode of treatment of RCC was the surgical procedure with laparoscopy, which was undergone in 52.1% of cases.
ccRCC exhibits the highest prevalence among the various forms of renal cancer, with the majority of cases being diagnosed incidentally. Despite the rising incidence, early diagnosis and improved screening strategies are yet to be elucidated to address the growing burden of RCC and its incidental finding rate in the Qassim region.
肾细胞癌（RCC）是一种侵袭性恶性肿瘤，占肾癌的90%，在全球范围内发病率呈上升趋势。本研究旨在分析沙特阿拉伯卡西姆地区一家医院73例肾细胞癌患者的人口统计学和临床特征、组织病理学表现及治疗结果。
本回顾性观察研究于2017年10月至2024年7月在布赖代的法赫德国王专科医院进行。普查抽样包括所有诊断为肾细胞癌的患者。使用SPSS 26版（纽约州阿蒙克：IBM公司）分析人口统计学、临床和组织病理学特征数据。
肾细胞癌在男性和老年患者中更为常见，常伴有糖尿病和高血压等合并症。在肾细胞癌的组织病理学类型中，透明细胞肾细胞癌（ccRCC）最常见，占患者的60.3%，其次是嫌色细胞肾细胞癌（chRCC）和乳头状肾细胞癌（pRCC），分别占患者的16.4%和11%。65.8%的肿瘤为福尔曼2级，表明其为中度侵袭性形式。偶然诊断的患者占45.2%，93.2%的患者在诊断时无转移证据。肾细胞癌的主要治疗方式是腹腔镜手术，52.1%的病例接受了该手术。
ccRCC在各种形式的肾癌中患病率最高，大多数病例为偶然诊断。尽管发病率不断上升，但在卡西姆地区，早期诊断和改进筛查策略仍有待阐明，以应对肾细胞癌及其偶然发现率不断增加的负担。
