Addo H A, Ferguson J, Frain-Bell W
Br J Dermatol. 1987 Jun;116(6):749-60. doi: 10.1111/j.1365-2133.1987.tb04893.x.
The clinical features, action spectrum and subsequent course, are described in 33 subjects with thiazide-induced photosensitivity. The reaction appeared to be phototoxic in nature. The wavelengths involved were those of the longer UVA and, not infrequently, also the shorter UVB waveband. In most instances withdrawal of the drug resulted in clearance of the clinical reaction and a return of the action spectrum to normal. In the few subjects in whom the photosensitivity persisted, either in the form of the clinical reaction or an abnormal action spectrum, or both, either a specific photodermatosis was present or another potentially photoactive drug was being taken. In no instance, was there evidence of the induction of long-term chronic photosensitivity (persistent light reaction) following the withdrawal of the thiazide drug.
本文描述了33例噻嗪类药物引起的光敏反应患者的临床特征、作用光谱及后续病程。该反应本质上似乎是光毒性的。涉及的波长为较长的UVA波段，且短UVB波段也不少见。在大多数情况下，停药后临床反应消退，作用光谱恢复正常。少数患者的光敏反应持续存在，表现为临床反应或异常作用光谱，或两者皆有，这些患者要么患有特定的光皮肤病，要么正在服用另一种潜在的光敏药物。在任何情况下，都没有证据表明停用噻嗪类药物后会诱发长期慢性光敏反应（持续性光反应）。
