Moore D E
J Pharm Sci. 1977 Sep;66(9):1282-4. doi: 10.1002/jps.2600660919.
UV irradiation (365 nm) of air-saturated methanol solutions of 20 drugs absorbing in the 300--400 nm region gave rise to oxygen uptake, as determined with a polarographic oxygen electrode. The drugs were tested for photosensitizing capability by either a Type I (free radical) or a Type II (single molecular oxygen) mechanism. This testing was done by the inclusion of either acrylamide or 2,5-dimethylfuran in the irradiated drug solution, with observation of the subsequent polymerization or oxidation, respectively. Phenothiazine and thiazide derivatives appear capable of photosensitization by both mechanisms; promethazine, trifluoperazine, and furosemide show relatively high reactivity. Diazepam (weak), hexachlorophene, aminacrine, pyrilamine, tetracycline, demeclocycline, quinine, and anthracene (strong) react only by a Type II mechanism, with a photosensitizing efficiency increasing in the order given. A correlation appears to exist with reports of in vivo photosensitivity.
用极谱氧电极测定，对在300 - 400nm区域有吸收的20种药物的空气饱和甲醇溶液进行紫外线（365nm）照射会导致氧气吸收。通过I型（自由基）或II型（单重态分子氧）机制对这些药物的光敏能力进行了测试。该测试通过在照射的药物溶液中加入丙烯酰胺或2,5 - 二甲基呋喃来进行，分别观察随后的聚合反应或氧化反应。吩噻嗪和噻嗪衍生物似乎能够通过两种机制进行光敏作用；异丙嗪、三氟拉嗪和呋塞米显示出相对较高的反应活性。地西泮（弱）、六氯酚、氨基吖啶、吡拉明、四环素、地美环素、奎宁和蒽（强）仅通过II型机制反应，其光敏效率按给定顺序增加。这似乎与体内光敏性的报道存在相关性。
