Agustiningsih Agustiningsih, Rasyak Muhammad Rezki, Jayanti Sri, Sukowati Caecilia
Eijkman Research Center for Molecular Biology, National Research and Innovation Agency of Indonesia (BRIN), Jakarta Pusat 10340, Indonesia.
Post Graduate School, Faculty of Medicine, Universitas Hasanuddin, Makassar 90245, Indonesia.
Explor Target Antitumor Ther. 2024;5(1):120-134. doi: 10.37349/etat.2024.00209. Epub 2024 Feb 20.
Hepatocellular carcinoma (HCC) is the most prevalent form of primary liver cancers with high mortality rate. Among its various etiological factors, one of the major risk factors for HCC is a chronic infection of hepatitis B virus (HBV). HBV X protein (HBx) has been identified to play an important role in the HBV-induced HCC pathogenesis since it may interfere with several key regulators of many cellular processes. HBx localization within the cells may be beneficial to HBx multiple functions at different phases of HBV infection and associated hepatocarcinogenesis. HBx as a regulatory protein modulates cellular transcription, molecular signal transduction, cell cycle, apoptosis, autophagy, protein degradation pathways, and host genetic stability via interaction with various factors, including its association with various non-coding RNAs. A better understanding on the regulatory mechanism of HBx on various characteristics of HCC would provide an overall picture of HBV-associated HCC. This article addresses recent data on HBx role in the HBV-associated hepatocarcinogenesis.
肝细胞癌（HCC）是原发性肝癌最常见的形式，死亡率很高。在其各种病因中，HCC的主要危险因素之一是乙型肝炎病毒（HBV）的慢性感染。HBV X蛋白（HBx）已被确定在HBV诱导的HCC发病机制中起重要作用，因为它可能干扰许多细胞过程的几个关键调节因子。HBx在细胞内的定位可能有利于HBx在HBV感染和相关肝癌发生的不同阶段发挥多种功能。HBx作为一种调节蛋白，通过与各种因子相互作用，包括与各种非编码RNA的关联，调节细胞转录、分子信号转导、细胞周期、凋亡、自噬、蛋白质降解途径和宿主遗传稳定性。更好地了解HBx对HCC各种特征的调节机制将提供与HBV相关的HCC的整体情况。本文阐述了关于HBx在HBV相关肝癌发生中作用的最新数据。
