Okoro Roland Nnaemeka, Abdullahi Kasim, Dayar Dauda Ayuba
Department of Clinical Pharmacy and Pharmacy Administration, Faculty of Pharmacy, University of Maiduguri, Maiduguri, Nigeria.
Gastroenterology Unit, Department of Internal Medicine, University of Maiduguri Teaching Hospital, Maiduguri, Nigeria.
Med Access Point Care. 2021 Dec 5;5:23992026211062729. doi: 10.1177/23992026211062729. eCollection 2021 Jan-Dec.
Proton-pump inhibitor (PPI) is a widely used medication class globally. Because of its good safety profile, there is a huge likelihood of inappropriate use.
To determine the prevalence of PPI use and indications, describe its pattern of usage, and identify factors associated with inappropriate prescriptions at a federal tertiary teaching hospital in Maiduguri, Nigeria.
PPI prescriptions were retrospectively assessed in the General Outpatients' Department (GOPD) and Gastroenterology Unit (GITU) of a teaching hospital. Relevant data for the study were extracted from the patients' medical records. Chi-square or Fisher's exact tests where appropriate were used to identify factors associated with inappropriate PPI prescriptions. A < 0.05 was considered to be significant.
PPIs were prescribed to 73.3% (220/300) of patients, while inappropriate prescriptions were noted in 91.4% (201/220) of these patients. Epigastric pain (49.5%) was the most common PPI indication, while omeprazole was the highest prescribed (53.4%). Nearly all inpatients (98.2%), those with epigastric pain (95.7%), and patients who were prescribed intravenous PPIs had more inappropriate PPI prescriptions compared to others.
This study revealed a high prevalence of PPI use and inappropriate prescriptions at the study hospital. As a result, these findings highlight the importance PPI-based stewardship program at the study hospital.
质子泵抑制剂（PPI）是全球广泛使用的一类药物。由于其良好的安全性，存在大量不当使用的可能性。
确定尼日利亚迈杜古里一家联邦三级教学医院PPI的使用情况和适应证，描述其使用模式，并确定与不适当处方相关的因素。
对一家教学医院的普通门诊部（GOPD）和胃肠病科（GITU）的PPI处方进行回顾性评估。从患者病历中提取研究相关数据。在适当情况下，使用卡方检验或费舍尔精确检验来确定与不适当PPI处方相关的因素。P < 0.05被认为具有统计学意义。
73.3%（220/300）的患者开具了PPI处方，其中91.4%（201/220）的处方不适当。上腹部疼痛（49.5%）是最常见的PPI适应证，而奥美拉唑的处方量最高（53.4%）。与其他患者相比，几乎所有住院患者（98.2%）、有上腹部疼痛的患者（95.7%）以及开具静脉PPI的患者有更多不适当的PPI处方。
本研究显示该研究医院PPI的使用率和不适当处方率较高。因此，这些发现凸显了该研究医院基于PPI的管理计划的重要性。
