Gong Wei, Shen Shuhan, Shi Xiaojing
Department of Emergency, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, China.
Front Cardiovasc Med. 2022 Sep 20;9:973592. doi: 10.3389/fcvm.2022.973592. eCollection 2022.
An understanding of the epidemiologic patterns of peripheral artery disease is essential in public health policy-making. We aimed to assess secular trends in the epidemiologic patterns and risk factors of peripheral artery disease from 1990 to 2019 in China.
We extracted data on prevalence, incidence, death, and disability-adjusted life years (DALYs) due to peripheral artery disease from the Global Burden of Disease study 2019. In addition, risk factors for peripheral artery disease were reported.
The age-standardized prevalence of peripheral artery disease significantly increased from 1330.42 to 1423.78 per 100,000 population, with an average annual percentage change (AAPC) of 0.16 [95% confidence interval (CI), 0.07 to 0.24] from 1990 to 2019 in China. In addition, the age-standardized mortality rate significantly increased, with an AAPC of 0.62 (95% CI, 0.54 to 0.7), contrasting with the significantly declining trend in age-standardized DALYs (AAPC, -0.45; 95% CI, -0.52 to -0.39) between 1990 and 2019. The age-standardized prevalence was almost three times higher in females than males [2022.13 (95% CI: 1750 to 2309.13) vs. 744.96 (95% CI: 644.62 to 850.82) per 100,000 population] in 2019. The age-specific incidence significantly increased in individuals aged 40-44, 45-49, 50-54, 55-59, and 60-64 years groups but decreased in 70-74, 75-79, and 80-84 years groups. The age and period effects showed that the relative risks of incident peripheral artery disease increased with age and time. The cohort assessment showed that the incidence decreased in successive birth cohorts. Smoking was identified as the risk factor that contributed the most to age-standardized DALYs of peripheral artery disease in 2019.
The burden of peripheral artery disease showed unexpected patterns that varied by age, sex, and year in China. More attention should be given to addressing the increasing incidence among middle-aged individuals and mortality among males.
了解外周动脉疾病的流行病学模式对于制定公共卫生政策至关重要。我们旨在评估1990年至2019年中国外周动脉疾病流行病学模式和危险因素的长期趋势。
我们从《2019年全球疾病负担研究》中提取了外周动脉疾病的患病率、发病率、死亡率和伤残调整生命年（DALYs）数据。此外，还报告了外周动脉疾病的危险因素。
1990年至2019年，中国外周动脉疾病的年龄标准化患病率从每10万人1330.42例显著增加至1423.78例，平均年增长率（AAPC）为0.16[95%置信区间（CI），0.07至0.24]。此外，年龄标准化死亡率显著上升，AAPC为0.62（95%CI，0.54至0.7），而1990年至2019年期间年龄标准化DALYs呈显著下降趋势（AAPC，-0.45；95%CI，-0.52至-0.39）。2与男性相比，2019年女性的年龄标准化患病率几乎高出三倍[每10万人2022.13例（95%CI：1750至2309.13）对744.96例（95%CI：644.62至850.82）]。40-44岁、45-49岁、50-54岁、55-59岁和60-64岁年龄组的年龄别发病率显著上升，但70-74岁、75-79岁和80-84岁年龄组的发病率下降。年龄和时期效应表明，新发外周动脉疾病的相对风险随年龄和时间增加。队列评估显示，连续出生队列的发病率下降。吸烟被确定为2019年对外周动脉疾病年龄标准化DALYs贡献最大的危险因素。
中国外周动脉疾病负担呈现出因年龄、性别和年份而异的意外模式。应更加关注解决中年人群发病率上升和男性死亡率上升的问题。
