Department of Interventional Radiology, Chengdu Municipal Third People's Hospital, Chengdu, China.
Department of Emergency, The First Hospital of China Medical University, Shenyang, China.
Front Public Health. 2022 Jul 28;10:930784. doi: 10.3389/fpubh.2022.930784. eCollection 2022.
Carbon monoxide (CO) poisoning is one of the most common toxic occupational diseases, but related data in China are scarce. A better understanding of the burden of CO poisoning is essential for improving its management.
A systematic analysis of data from the Global Burden of Disease (GBD) Study 2019 was conducted. Following the general analytical strategy used in the GBD Study 2019, the sex- and age-specific incidence and mortality rates of CO poisoning and disability-adjusted life years (DALYs) due to CO poisoning in China were analyzed. Estimated average annual percentage changes (AAPCs) in age-standardized rates were calculated by joinpoint regression analysis. The effects of age, period and cohort on the incidence of CO poisoning and DALYs due to CO poisoning were estimated by an age-period-cohort model.
The age-standardized incidence and mortality rates as well as DALYs of CO poisoning per 100,000 population were estimated to be 21.82 [95% uncertainty interval (UI): 15.05-29.98], 0.93 (95% UI: 0.63-1.11), and 40.92 (95% UI: 28.43-47.85), respectively, in 2019. From 1990 to 2019, the AAPCs in the age-standardized incidence significantly increased in both males and females, while the age-standardized mortality rates and DALYs significantly decreased in both males and females. The incidence of CO poisoning peaked in individuals aged 15-19 years. Males had a higher burden of CO poisoning than females. The age effect showed that the relative risks (RRs) of incident CO poisoning decreased with age among males and females and that individuals aged 15-24 years had the highest RRs. The RRs of incident CO poisoning increased with time. The cohort effect showed that the incidence increased in successive birth cohorts.
The incidence of CO poisoning in China increased from 1990 to 2019. More attention should be given to improving the burden of CO poisoning in Chinese adolescents. The results of this study can be used by health authorities to inform preventative measures to reduce the burden of CO poisoning.
一氧化碳（CO）中毒是最常见的职业中毒之一，但中国相关数据较为匮乏。更好地了解 CO 中毒负担对于改善其管理至关重要。
对 2019 年全球疾病负担（GBD）研究的数据进行了系统分析。按照 GBD 2019 研究的一般分析策略，分析了中国 CO 中毒的发病率、死亡率和因 CO 中毒导致的伤残调整生命年（DALY），以及中国 CO 中毒发病率和因 CO 中毒导致的 DALY 的年龄标准化率的估计年平均变化百分比（AAPC）。采用年龄-时期-队列模型估计 CO 中毒发病率和因 CO 中毒导致的 DALY 的年龄、时期和队列效应。
估计 2019 年中国每 10 万人中 CO 中毒的年龄标准化发病率、死亡率和 DALY 分别为 21.82[95%置信区间（95%UI）：15.05-29.98]、0.93（95%UI：0.63-1.11）和 40.92（95%UI：28.43-47.85）。1990 年至 2019 年，男性和女性的年龄标准化发病率的 AAPC 均显著增加，而男性和女性的年龄标准化死亡率和 DALY 均显著降低。CO 中毒的发病率在 15-19 岁人群中达到峰值。男性 CO 中毒负担高于女性。年龄效应表明，男性和女性的 CO 中毒发病率的相对风险（RR）随年龄增长而降低，15-24 岁年龄组 RR 最高。RR 随时间增加而增加。队列效应表明，连续出生队列的发病率均增加。
1990 年至 2019 年中国 CO 中毒的发病率呈上升趋势。应更加关注改善中国青少年的 CO 中毒负担。本研究结果可供卫生当局用于制定预防措施，以减轻 CO 中毒负担。
