Ma Zhi-Xuan, Liu Zhen, Xiong Hui-Hui, Zhou Zong-Pu, Ouyang Li-Si, Xie Fu-Kang, Tang Ya-Mei, Wu Zhong-Dao, Feng Ying
School of Medicine, South China University of Technology, Guangzhou, Guangdong Province, China.
Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong Province, China.
Neural Regen Res. 2023 Apr;18(4):734-745. doi: 10.4103/1673-5374.353481.
MicroRNAs (miRNAs) play an important regulatory role in neuronal growth and development. Different miRNAs target different genes to protect neurons in different ways, such as by avoiding apoptosis, preventing degeneration mediated by conditional mediators, preventing neuronal loss, weakening certain neurotoxic mechanisms, avoiding damage to neurons, and reducing inflammatory damage to them. The high expression of miRNAs in the brain has significantly facilitated their development as protective targets for therapy, including neuroprotection and neuronal recovery. miRNA is indispensable to the growth and development of neurons, and in turn, is beneficial for the development of the brain and checking the progression of various diseases of the nervous system. It can thus be used as an important therapeutic target for models of various diseases. This review provides an introduction to the protective effects of miRNA on neurons in case of different diseases or damage models, and then provides reference values and reflections on the relevant treatments for the benefit of future research in the area.
微小RNA（miRNA）在神经元生长和发育中发挥着重要的调节作用。不同的miRNA靶向不同的基因，通过不同方式保护神经元，如避免细胞凋亡、防止由条件介质介导的退化、防止神经元丢失、削弱某些神经毒性机制、避免对神经元的损伤以及减少对它们的炎症损伤。miRNA在大脑中的高表达显著促进了它们作为治疗性保护靶点的发展，包括神经保护和神经元恢复。miRNA对神经元的生长和发育不可或缺，反过来，对大脑发育以及抑制各种神经系统疾病的进展有益。因此，它可作为各种疾病模型的重要治疗靶点。本综述介绍了miRNA在不同疾病或损伤模型情况下对神经元的保护作用，然后为相关治疗提供参考价值和思考，以利于该领域未来的研究。
