Patranabis Somi
Amity University, Kolkata, West Bengal, India.
Neuromolecular Med. 2024 Dec 8;26(1):52. doi: 10.1007/s12017-024-08820-2.
The review aims to focus on the role of miRNA in gene regulation, related to differentiation and apoptosis of neurons, focusing on the array of miRNAs involved in the processes. miRNAs are a known class of small regulatory RNAs, which in association with RNA processing bodies, play major roles in different cellular events, such as neurogenesis and neuronal differentiation. miRNAs function in controlling neuronal events by targeting different important molecules of cellular signalling. The post-translational modification of Ago2 is crucial in modulating the neurons' miRNA-mediated regulation. Thus, understanding the crosstalk between cellular signalling and miRNA activity affecting neuronal events is very important to decipher novel targets and related signalling pathways, involved in neuronal survival and neurodegeneration.
本综述旨在聚焦微小RNA（miRNA）在基因调控中的作用，该作用与神经元的分化和凋亡相关，重点关注参与这些过程的一系列miRNA。miRNA是一类已知的小调节RNA，其与RNA加工小体相关，在不同的细胞事件（如神经发生和神经元分化）中发挥主要作用。miRNA通过靶向细胞信号传导的不同重要分子来控制神经元事件。AGO2的翻译后修饰在调节神经元的miRNA介导的调控中至关重要。因此，了解影响神经元事件的细胞信号传导与miRNA活性之间的相互作用，对于解读参与神经元存活和神经退行性变的新靶点及相关信号通路非常重要。
