Tan Janice Lay Tin, Shimabukuro Masaya, Kishida Ryo, Ishikawa Kunio
Faculty of Dental Science, Kyushu University, Fukuoka, Japan.
Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan.
J Biomed Mater Res B Appl Biomater. 2023 Mar;111(3):560-567. doi: 10.1002/jbm.b.35173. Epub 2022 Oct 7.
The composition of carbonate apatite (CO Ap) aids bone regeneration. Other features, such as porosity and pore interconnectivity of artificial bone, also govern bone regeneration. In general, a trade-off exists between the porosity and mechanical strength of artificial bone. Therefore, this suggests that the interconnected pores in the ant-nest-type porous (ANP) structure of artificial bone accelerate bone regeneration by minimizing the sacrifice of mechanical strength. The unique structure of polyurethane foam has the potential to endow CO Ap with an ANP structure without forming excess pores. This study investigated the efficacy of polyurethane foam as a porogen in providing ANP structure to CO Ap artificial bone. The polyurethane foam was completely decomposed by sintering and the resulting CO Ap displayed ANP structure with a compressive strength of approximately 15 MPa. Furthermore, in vivo experiments revealed that the migration of cells and tissues into the interior of CO Ap through the interconnected pores accelerated bone regeneration in the ANP-structured CO Ap. Thus, this indicates that using polyurethane foam as a porogen endows the CO Ap artificial bone with an ANP structure that accelerates bone regeneration.
碳酸磷灰石（CO Ap）的成分有助于骨再生。人工骨的其他特性，如孔隙率和孔隙连通性，也对骨再生起控制作用。一般来说，人工骨的孔隙率和机械强度之间存在权衡。因此，这表明人工骨蚁巢型多孔（ANP）结构中的连通孔隙通过将机械强度的牺牲降至最低来加速骨再生。聚氨酯泡沫的独特结构有可能赋予CO Ap一种ANP结构，而不会形成过多孔隙。本研究调查了聚氨酯泡沫作为致孔剂为CO Ap人工骨提供ANP结构的效果。通过烧结，聚氨酯泡沫完全分解，所得的CO Ap呈现出ANP结构，抗压强度约为15兆帕。此外，体内实验表明，细胞和组织通过连通孔隙迁移到CO Ap内部，加速了ANP结构的CO Ap中的骨再生。因此，这表明使用聚氨酯泡沫作为致孔剂可赋予CO Ap人工骨一种加速骨再生的ANP结构。
