Section of Orthodontics, Division of Oral Health, Growth and Development, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.
Department of Biomaterials, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.
J Tissue Eng Regen Med. 2022 Feb;16(2):200-206. doi: 10.1002/term.3270. Epub 2021 Dec 8.
Carbonate apatite (CO Ap), an inorganic component of human bone, has been clinically applied as an artificial bone substitute. In this study, the effects of the CO content in CO Ap on the replacement by new bone were studied by fabricating CO Ap granules containing 0.9-8.3 wt% of CO . The dissolution rate of CO Ap in a weak acidic solution, mimicking the Howship's lacunae, was rapid for the CO Ap granules containing a larger amount of CO . Histological analyses demonstrated the rapid resorption in CO Ap and replacement by natural bone tissue when the CO content was increased. Therefore, the CO content in CO Ap is a key factor that influences the replacement of the bone tissue.
碳酸磷灰石（COAp）是人体骨骼的无机成分，已在临床上用作人工骨替代物。在这项研究中，通过制备含有 0.9-8.3wt%CO 的 COAp 颗粒，研究了 COAp 中 CO 含量对新骨替代的影响。COAp 在弱酸性溶液（模拟 Howship 陷窝）中的溶解速率对于含有大量 CO 的 COAp 颗粒较快。组织学分析表明，当 CO 含量增加时，COAp 迅速吸收并被天然骨组织替代。因此，COAp 中的 CO 含量是影响骨组织替代的关键因素。
