Institute of Neuroscience and Psychology, University of Glasgow, Glasgow, UK.
School of Health and Wellbeing, University of Glasgow, Glasgow, UK.
Early Interv Psychiatry. 2023 Mar;17(3):327-330. doi: 10.1111/eip.13357. Epub 2022 Oct 7.
Language disturbances are a candidate biomarker for the early detection of psychosis. Temporal and prosodic abnormalities have been observed in schizophrenia patients, while there is conflicting evidence whether such deficits are present in participants meeting clinical high-risk for psychosis (CHR-P) criteria.
Clinical interviews from CHR-P participants (n = 50) were examined for temporal and prosodic metrics and compared against a group of healthy controls (n = 17) and participants with affective disorders and substance abuse (n = 23).
There were no deficits in acoustic variables in the CHR-P group, while participants with affective disorders/substance abuse were characterized by slower speech rate, longer pauses and higher unvoiced frames percentage.
Our finding suggests that temporal and prosodic aspects of speech are not impaired in early-stage psychosis. Further studies are required to clarify whether such abnormalities are present in sub-groups of CHR-P participants with elevated psychosis-risk.
语言障碍是早期精神病检测的候选生物标志物。在精神分裂症患者中观察到了时间和韵律异常，而对于符合精神病高危（CHR-P）标准的参与者是否存在这些缺陷，存在相互矛盾的证据。
对 CHR-P 参与者（n=50）的临床访谈进行了时间和韵律度量检查，并与一组健康对照者（n=17）和患有情感障碍和物质滥用的参与者（n=23）进行了比较。
CHR-P 组的声学变量没有缺陷，而患有情感障碍/物质滥用的参与者的言语速度较慢，停顿时间较长，无声帧百分比较高。
我们的发现表明，早期精神病患者的言语时间和韵律方面没有受损。需要进一步的研究来阐明在具有较高精神病风险的 CHR-P 参与者亚组中是否存在这种异常。
