Stanislawski Emma R, Bilgrami Zarina R, Sarac Cansu, Garg Sahil, Heisig Stephen, Cecchi Guillermo A, Agurto Carla, Corcoran Cheryl M
Icahn School of Medicine at Mount Sinai, New York, NY, USA.
IBM T.J. Watson Research Center, Yorktown Heights, NY, USA.
NPJ Schizophr. 2021 Jan 22;7(1):3. doi: 10.1038/s41537-020-00132-1.
Aberrant pauses are characteristic of schizophrenia and are robustly associated with its negative symptoms. Here, we found that pause behavior was associated with negative symptoms in individuals at clinical high risk (CHR) for psychosis, and with measures of syntactic complexity-phrase length and usage of determiners that introduce clauses-that we previously showed in this same CHR cohort to help comprise a classifier that predicted psychosis. These findings suggest a common impairment in discourse planning and verbal self-monitoring that affects both speech and language, and which is detected in clinical ratings of negative symptoms.
异常停顿是精神分裂症的特征，且与该疾病的阴性症状密切相关。在此，我们发现，停顿行为与临床高危（CHR）精神病个体的阴性症状相关，也与句法复杂性的指标——短语长度以及引导从句的限定词的使用相关，我们之前在同一CHR队列中表明这有助于构成一个预测精神病的分类器。这些发现表明在语篇规划和言语自我监控方面存在一种共同的损伤，这种损伤影响言语和语言，并且在阴性症状的临床评定中能够检测到。
