Leder L D
Klin Wochenschr. 1978 Nov 15;56(22):1091-6. doi: 10.1007/BF01477130.
The terms "reticulosis" and "reticulum cell sarcoma" (=malignant lymphoma, histiocytic type) are discussed regarding the modern concept of the monocyte macrophage system which today has replaced the ancient theory of the reticuloendothelial system. The monocyte macrophage system which today has replaced the ancient theory of the reticuloendothelial system. The monocyte macrophage system is not independent, but closely related to the myeloid system. Thus, a third blood forming system as was believed in the case of RES does not exist. Phagocytic reticulum cells of the various henatopoietic organs are highly activated monocyte-derived macrophages. All those conditions formerly termed "reticulosses" have been found to belong either to the myeloid or to the lymphatic system. Considering the reticulum cell sarcomas or malignant histiocytic lymphomas, most of them seem to be of lymphatic rather than of macrophage origin, representing highgrade malignant lymphomas, possibly immunoblastic sarcomas. No relationship between these tumours and the monocyte macrophage system has been established, so far. Therefore, the terms "reticulosis" and "reticulum cell sarcoma" should be no longer used in order to avoid confusion, in order to stimulate sufficient diagnostic efforts which will really clarify such cases, and in order to give full credit to modern results of hematopathology.
关于单核巨噬细胞系统的现代概念，对“网状细胞增多症”和“网状细胞肉瘤”（=恶性淋巴瘤，组织细胞型）进行了讨论，如今单核巨噬细胞系统已取代了古老的网状内皮系统理论。单核巨噬细胞系统如今已取代了古老的网状内皮系统理论。单核巨噬细胞系统并非独立存在，而是与髓系密切相关。因此，并不存在如网状内皮系统那样被认为的第三个造血系统。各造血器官的吞噬性网状细胞是高度活化的单核细胞衍生的巨噬细胞。所有那些以前被称为“网状细胞增多症”的病症已被发现要么属于髓系，要么属于淋巴系。考虑到网状细胞肉瘤或恶性组织细胞性淋巴瘤，其中大多数似乎起源于淋巴系而非巨噬细胞系，代表高度恶性淋巴瘤，可能是免疫母细胞肉瘤。到目前为止，尚未确立这些肿瘤与单核巨噬细胞系统之间的关系。因此，为避免混淆，为促使进行充分的诊断努力以真正明确此类病例，并为充分认可血液病理学的现代研究成果，不应再使用“网状细胞增多症”和“网状细胞肉瘤”这两个术语。
