Department of Dermatology, Fondazione IRCCS Ca' Granda "Ospedale Maggiore Policlinico", Università degli Studi di Milano, Milan, Italy.
Associazione DDI - Donne Dermatologhe, Napoli, Italy.
J Dermatolog Treat. 2023 Dec;34(1):2131703. doi: 10.1080/09546634.2022.2131703. Epub 2022 Oct 17.
To investigate the efficacy and tolerability of a cream (Rilastil Xerolact PB) containing a mixture of prebiotics and postbiotics, and to validate the PRURISCORE itch scale in the management of atopic dermatitis. The study is based on 396 subjects of both sexes in three age groups (i.e., infants, children, adults) suffering from mild/moderate Atopic Dermatitis, recruited from 8 European countries and followed for 3 months. The product demonstrated good efficacy combined with good/very good tolerability in all age groups. In particular, SCORAD, PRURISCORE and IGA scores decreased significantly over the course of the study. The PRURISCORE was preferred to VAS by the vast majority of patients. Even though the role of prebiotics and postbiotics was not formally demonstrated since these substances were part of a complex formulation, it can be reasonably stated that prebiotics and postbiotics have safety and standardization features that probiotics do not have. In addition they are authorized by regulatory authorities, whereas topical probiotics are not.
为了研究一种含有益生元和后生元混合物的乳膏（Rilastil Xerolact PB）的疗效和耐受性，并验证 PRURISCORE 瘙痒量表在特应性皮炎管理中的有效性。该研究基于来自 8 个欧洲国家的 396 名不同性别和 3 个年龄组（婴儿、儿童和成人）的患有轻度/中度特应性皮炎的患者，随访时间为 3 个月。该产品在所有年龄组均表现出良好的疗效和良好/非常好的耐受性。特别是，SCORAD、PRURISCORE 和 IGA 评分在研究过程中显著下降。绝大多数患者更喜欢 PRURISCORE 而不是 VAS。尽管由于这些物质是复杂配方的一部分，益生元和后生元的作用没有得到正式证明，但可以合理地说，益生元和后生元具有益生菌所没有的安全性和标准化特征。此外，它们得到了监管机构的授权，而局部益生菌则没有。
