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局部用益生菌在皮肤病治疗和皮肤护理中的全球趋势及科学影响

Global Trends and Scientific Impact of Topical Probiotics in Dermatological Treatment and Skincare.

作者信息

Alves Ademilton Costa, Martins Sergio Murilo da Silva Braga, Belo José Victor Trindade, Lemos Mauro Victor Castro, Lima Carlos Emanuel de Matos Chaves, Silva Carlos Drielson da, Zagmignan Adrielle, Nascimento da Silva Luís Cláudio

机构信息

Laboratório de Patogenicidade Microbiana, Universidade CEUMA, São Luis 65075-120, MA, Brazil.

出版信息

Microorganisms. 2024 Oct 3;12(10):2010. doi: 10.3390/microorganisms12102010.


DOI:10.3390/microorganisms12102010
PMID:39458319
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11510400/
Abstract

The skin plays a crucial role in maintaining homeostasis and protecting against external aggressors. Recent research has highlighted the potential of probiotics and postbiotics in dermatological treatments and skincare. These beneficial microorganisms interact with the skin microbiota, modulate the immune response, and enhance the skin barrier, offering a promising therapeutic avenue for various skin conditions, such as acne, dermatitis, eczema, and psoriasis. This bibliometric study aims to analyze the global trends and scientific impact of topical probiotics in dermatology. By reviewing 106 articles published between 2013 and 2023, the study categorizes the applications of probiotics in wound healing, inflammatory skin diseases, and general skincare. The findings indicate a significant increase in publications from 2021 onwards, attributed to the heightened focus on medical research during the COVID-19 pandemic. This study also identifies the most productive countries, institutions, and authors in this field, highlighting the importance of international collaborations. The results underscore the efficacy of probiotic-based topical formulations in improving skin health, reducing inflammation, and enhancing wound healing. This comprehensive analysis supports the development of new therapeutic strategies based on topical probiotics and encourages high-quality research in this promising area.

摘要

皮肤在维持体内平衡和抵御外部侵害方面起着至关重要的作用。最近的研究突出了益生菌和后生元在皮肤病治疗和皮肤护理中的潜力。这些有益微生物与皮肤微生物群相互作用,调节免疫反应,增强皮肤屏障,为痤疮、皮炎、湿疹和银屑病等各种皮肤疾病提供了一条有前景的治疗途径。这项文献计量学研究旨在分析局部应用益生菌在皮肤病学领域的全球趋势和科学影响。通过回顾2013年至2023年间发表的106篇文章,该研究对益生菌在伤口愈合、炎症性皮肤病和一般皮肤护理中的应用进行了分类。研究结果表明,自2021年起出版物数量显著增加,这归因于新冠疫情期间对医学研究的关注度提高。该研究还确定了该领域最具生产力的国家、机构和作者,强调了国际合作的重要性。结果强调了基于益生菌的局部制剂在改善皮肤健康、减轻炎症和促进伤口愈合方面的功效。这一全面分析支持基于局部益生菌的新治疗策略的开发,并鼓励在这一有前景的领域开展高质量研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc50/11510400/d88de3982f97/microorganisms-12-02010-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc50/11510400/978714b8288b/microorganisms-12-02010-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc50/11510400/06934736a4d0/microorganisms-12-02010-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc50/11510400/b342e892cb4a/microorganisms-12-02010-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc50/11510400/a9cefc4d35fd/microorganisms-12-02010-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc50/11510400/08ee25e6fe9f/microorganisms-12-02010-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc50/11510400/b6bfe241c8d2/microorganisms-12-02010-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc50/11510400/85334b05f5a5/microorganisms-12-02010-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc50/11510400/8f8339678b93/microorganisms-12-02010-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc50/11510400/53fcda8e91c1/microorganisms-12-02010-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc50/11510400/165011e53af8/microorganisms-12-02010-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc50/11510400/ba714311ae79/microorganisms-12-02010-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc50/11510400/9f22b7f809cc/microorganisms-12-02010-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc50/11510400/d88de3982f97/microorganisms-12-02010-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc50/11510400/978714b8288b/microorganisms-12-02010-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc50/11510400/06934736a4d0/microorganisms-12-02010-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc50/11510400/b342e892cb4a/microorganisms-12-02010-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc50/11510400/a9cefc4d35fd/microorganisms-12-02010-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc50/11510400/08ee25e6fe9f/microorganisms-12-02010-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc50/11510400/b6bfe241c8d2/microorganisms-12-02010-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc50/11510400/85334b05f5a5/microorganisms-12-02010-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc50/11510400/8f8339678b93/microorganisms-12-02010-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc50/11510400/53fcda8e91c1/microorganisms-12-02010-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc50/11510400/165011e53af8/microorganisms-12-02010-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc50/11510400/ba714311ae79/microorganisms-12-02010-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc50/11510400/9f22b7f809cc/microorganisms-12-02010-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc50/11510400/d88de3982f97/microorganisms-12-02010-g013.jpg

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[2]
IL-17A inhibitors modulate skin microbiome in psoriasis: implications for microbial homeostasis.

J Transl Med. 2025-7-24

[3]
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Int J Mol Sci. 2025-5-22

[4]
Microbiome and Postbiotics in Skin Health.

Biomedicines. 2025-3-25

[5]
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Probiotics Antimicrob Proteins. 2025-4-17

[6]
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J Cosmet Dermatol. 2025-4

本文引用的文献

[1]
Natural Topical Treatment Contributes to a Reduction of Dry Scalp Symptoms in Children.

Clin Cosmet Investig Dermatol. 2023-10-4

[2]
Effects of a lotion containing probiotic ferment lysate as the main functional ingredient on enhancing skin barrier: a randomized, self-control study.

Sci Rep. 2023-10-6

[3]
Looking into the Skin in Health and Disease: From Microscopy Imaging Techniques to Molecular Analysis.

Int J Mol Sci. 2023-9-6

[4]
Human Wound and Its Burden: Updated 2022 Compendium of Estimates.

Adv Wound Care (New Rochelle). 2023-12

[5]
The Skin Barrier and Moisturization: Function, Disruption, and Mechanisms of Repair.

Skin Pharmacol Physiol. 2023

[6]
The Potential of ATCC 14917 in the Development of Alginate-Based Gel Formulations with Anti- Properties.

Pharmaceuticals (Basel). 2023-8-7

[7]
Living, quiescent Lactobacillus plantarum Lp90 probiotic, delivered topically to full thickness tissues in vitro via a just-add-water cream delivery system, stimulates the expression of elastin protein.

J Cosmet Dermatol. 2023-10

[8]
Topical Application of M89PF Containing Vichy Mineralising Water and Probiotic Fractions Prevents Cutaneous Damage Induced by Exposure to UV and O.

Clin Cosmet Investig Dermatol. 2023-7-8

[9]
The pivotal role of Bifida Ferment Lysate on reinforcing the skin barrier function and maintaining homeostasis of skin defenses in vitro.

J Cosmet Dermatol. 2023-12

[10]
Role of UBLP-40, UBLR-58 and UBBL-64 in the Wound Healing Process of the Excisional Skin.

Nutrients. 2023-4-10

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