Mahmoodi Nesheli Mohsen, Khorasani Ghasemali, Hosseinimehr Seyed Jalal, Rahmati Javad, Yavari Ali
Department of Plastic and Reconstructive Surgery, Imam Khomeini Hospital Complex, Medicine Faculty, Tehran University of Medical Sciences, Tehran, Iran.
Department of Radiopharmacy, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
J Integr Complement Med. 2022 Dec;28(12):948-954. doi: 10.1089/jicm.2022.0533. Epub 2022 Oct 7.
The wound healing process involves a complex series of biological events. Skin grafts have several uses as a reconstructive method. There are several dressings for the skin graft donor site, but the optimum dressing agents that provide all the requirements at the same time are unclear. This prospective, randomized, placebo-controlled clinical trial aimed to evaluate the therapeutic effect of cream in the wound healing process of partial-thickness skin graft donor sites and compared it with a placebo. This clinical trial study was performed on patients who underwent split-thickness skin grafts. Enrolled patients applied cream and placebo controlled (petrolatum ointment) twice a day, from the day of intervention at the skin graft donor sites in two parts, separately. On 7, 14, 21, and 28 days after surgery, the wound healing process was evaluated, photographed, and scored according to the Bates-Jensen assessment tool. Evidence of infection was evaluated. The main agent and placebo were compared during the wound healing process. Decreases in wound surface area and total score were significantly greater in the group ( < 0.05). The wounds of 30% of patients in the second week and 90% of patients in the third week were completely epithelialized in the group. These values were 3.3% and 36.7% for the control group, respectively, and so, the healing rate was ∼9-fold in the second week and 2.45-fold in the third week in the group compared with the control group ( < 0.05). Wound healing and reepithelialization accelerated significantly in the first, second, third, and fourth week after intervention in the treatment group, due to modulating the inflammatory phase and improving the proliferative phase. IRCT20210624051695N1.
伤口愈合过程涉及一系列复杂的生物学事件。皮肤移植作为一种重建方法有多种用途。皮肤移植供区有多种敷料，但能同时满足所有要求的最佳敷料尚不清楚。这项前瞻性、随机、安慰剂对照临床试验旨在评估乳膏在部分厚度皮肤移植供区伤口愈合过程中的治疗效果，并与安慰剂进行比较。这项临床试验研究是对接受中厚皮片移植的患者进行的。入选患者从干预当天起，在皮肤移植供区的两个部位分别每天涂抹两次乳膏和安慰剂对照（凡士林软膏）。在术后第7、14、21和28天，根据贝茨 - 詹森评估工具对伤口愈合过程进行评估、拍照和评分。评估感染迹象。在伤口愈合过程中对主要药物和安慰剂进行比较。乳膏组伤口表面积和总分的下降幅度显著更大（<0.05）。乳膏组第二周30%的患者伤口和第三周90%的患者伤口完全上皮化。对照组的这些值分别为3.3%和36.7%，因此，与对照组相比，乳膏组在第二周的愈合率约为9倍，第三周为2.45倍（<0.05）。由于调节炎症期和改善增殖期，乳膏治疗组在干预后的第一、第二、第三和第四周伤口愈合和再上皮化明显加速。IRCT20210624051695N1。
