Kheiri Aliasghar, Amini Shahideh, Javidan Abbas Norouzi, Saghafi Mohammad Mehdi, Khorasani Ghasemali
Plastic and Reconstructive Surgery Division, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Clinical Pharmacy Department, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
BMC Complement Altern Med. 2017 May 8;17(1):253. doi: 10.1186/s12906-017-1741-0.
A prospective, randomized, placebo-controlled clinical trial was conducted to compare the healing effectiveness of Alkanna tinctoria (L.) Tausch (Boraginaceae) with standard dressing on wound healing at the donor site after removal of the skin graft.
Enrolled patients were randomly allocated to receive topicalA. tinctoria extract ointment (20%) or standard dressing (dressing with base ointment) daily. Wound healing was assessed using the Bates-Jenson assessment tool at the 2 and 4 weeks after intervention.
Decreases in wound score were significantly greater in the A. tinctoria group compared with the placebo group (P <0.05). The surface areas of graft donor sites in the A. tinctoria group were significantly reduced as compared with the control group at day 28 of the intervention (P < 0.05). The proportion of patients in the A. tinctoria group achieving complete wound healing within 2 to 4 weeks was 50% and 96.66%, respectively, significantly higher than in patients receiving standard care: 0% and 23.3%, respectively.
This clinical study showed that A. tinctoria dressing accelerates wound healing after graft harvesting.
IRCT ID: IRCT201511165781N2 .
开展了一项前瞻性、随机、安慰剂对照临床试验，比较紫朱草（紫草科）与标准敷料对皮肤移植供区伤口愈合的疗效。
将入选患者随机分为两组，分别每日接受外用紫朱草提取物软膏（20%）或标准敷料（基础软膏敷料）。在干预后第2周和第4周，使用贝茨-詹森评估工具评估伤口愈合情况。
与安慰剂组相比，紫朱草组的伤口评分下降幅度显著更大（P<0.05）。在干预第28天，紫朱草组移植供区的表面积与对照组相比显著减小（P<0.05）。紫朱草组在2至4周内实现完全伤口愈合的患者比例分别为50%和96.66%，显著高于接受标准护理的患者，分别为0%和23.3%。
这项临床研究表明，紫朱草敷料可加速植皮术后伤口愈合。
IRCT ID：IRCT201511165781N2 。
