University of South Dakota Sanford School of Medicine, Sioux Falls, South Dakota.
Sanford Children's Hospital, Sioux Falls, South Dakota.
S D Med. 2022 Jun;75(6):274-277.
Pulmonary tumor thrombotic microangiopathy (PTTM) is a pulmonary hypertensive arteriopathy thought to be caused by activation of the coagulation cascade at the surface of circulating tumor microemboli along with intimal proliferation in small pulmonary arteries in patients with metastatic carcinomas. The subsequent stenosis of the pulmonary vasculature leads to pulmonary hypertension (PH) and, cor pulmonale with eventual respiratory compromise leading to respiratory failure. PTTM is always a nearly fatal disease with most cases diagnosed postmortem. Most cases reported on this condition are from Japan where the incidence of gastric malignancy is relatively higher than other parts of the world. We report a case of a Caucasian man with a classic presentation of PTTM to help make physicians aware of this rare, rapidly progressive and usually fatal phenomenon.
肺肿瘤血栓性微血管病（PTTM）是一种肺动脉高压性血管病，被认为是由循环肿瘤微栓子表面的凝血级联激活以及转移性癌患者的小肺动脉内膜增殖引起的。随后的肺血管狭窄导致肺动脉高压（PH）和肺心病，最终导致呼吸功能障碍导致呼吸衰竭。PTTM 总是一种几乎致命的疾病，大多数病例是在死后诊断出来的。这种情况的大多数病例都来自日本，那里的胃癌发病率相对高于世界其他地区。我们报告了一例白人男性 PTTM 的典型表现病例，以帮助医生认识这种罕见的、迅速进展且通常致命的现象。
