Souers Stroke Institute, Department of Neurology, Saint Louis University School of Medicine, SLUCare Academic Pavilion, 1008 S. Spring Ave, Suite 3700, Saint Louis, MO 63110, United States..
College for Public Health and Social Justice, Saint Louis University, United States.
J Stroke Cerebrovasc Dis. 2022 Dec;31(12):106814. doi: 10.1016/j.jstrokecerebrovasdis.2022.106814. Epub 2022 Oct 4.
To determine the odds of stroke in women of reproductive age who have had metabolic or bariatric surgery (MBS).
We used the National Inpatient Sample (NIS), a publicly available dataset that samples 20% of hospital discharges. The study population includes women between the ages of 20 and 44 without a maternal admission code. Weighted logistic regression analyses were conducted to assess the odds of stroke in women with history of MBS compared to other women of reproductive age. Adjustment of odds was done for the following covariates: age, race, primary payer, severity of illness, depression, and obesity.
Women with a history of MBS had 52% lower adjusted odds of having a stroke than women who did not have MBS (OR = 0.48, 95%CI = 0.42-0.55). Additionally, women who had MBS had lower odds of risk factors for stroke, including diabetes (OR = 0.61, 95%CI = 0.59-0.63), hypertension (OR = 0.82, 95%CI = 0.81-0.84), hypercholesterolemia (OR=0.72, 95%CI =0.68-0.77), and migraine with aura (OR = 0.86, 95%CI = 0.74-0.99).
Among women of reproductive age with a history of MBS, there were lower odds of having a stroke and stroke risk factors when compared to women who did not have MBS. Additionally, this study showed a modest decrease in the odds of stroke among women with obesity when adjusted for other risk factors. Future research should focus on examining this finding further, with a focus on the moderation of the impact of having obesity on stroke risk independent of other stroke risk factors.
确定接受代谢或减重手术（MBS）的育龄妇女中风的几率。
我们使用了国家住院患者样本（NIS），这是一个公开的数据集，涵盖了 20%的住院患者。研究人群包括年龄在 20 至 44 岁之间、没有产妇入院代码的女性。我们采用加权逻辑回归分析来评估有 MBS 病史的女性与其他育龄女性相比发生中风的几率。对以下协变量进行了几率调整：年龄、种族、主要支付方、疾病严重程度、抑郁和肥胖。
有 MBS 病史的女性发生中风的调整后几率比没有 MBS 的女性低 52%（OR=0.48，95%CI=0.42-0.55）。此外，接受 MBS 的女性发生中风的风险因素的几率也较低，包括糖尿病（OR=0.61，95%CI=0.59-0.63）、高血压（OR=0.82，95%CI=0.81-0.84）、高胆固醇血症（OR=0.72，95%CI=0.68-0.77）和有先兆偏头痛（OR=0.86，95%CI=0.74-0.99）。
在有 MBS 病史的育龄妇女中，与没有 MBS 的女性相比，发生中风和中风风险因素的几率较低。此外，本研究还表明，在调整其他风险因素后，肥胖女性发生中风的几率适度降低。未来的研究应进一步关注这一发现，重点关注肥胖对中风风险的影响是否独立于其他中风风险因素。
