Kulitskaia V I, Barinova M V
Biull Eksp Biol Med. 1987 Aug;104(8):157-60.
In experiments on rats it has been demonstrated that in the early post-traumatic period of chest contusion the appearance of respiratory insufficiency of the arterial-hypoxemia type is followed by increase of free-radical lipid peroxidation products of the lungs. To demonstrate the specific significance of these processes in decrease of PaO2 value is impossible, as submolecular changes in the lungs appear simultaneously with functional disorders. In the first week after trauma the mechanism of these processes in the normal parts of lungs is connected with activation of anabolic processes, but in the injured parts of lungs with activation of catabolic processes.
在对大鼠的实验中已证明，在胸部挫伤后的创伤早期，动脉低氧血症型呼吸功能不全出现后，肺组织中自由基脂质过氧化产物会增加。由于肺组织中的亚分子变化与功能障碍同时出现，因此无法证明这些过程在降低动脉血氧分压值方面的具体意义。创伤后的第一周，肺正常部位这些过程的机制与合成代谢过程的激活有关，但在肺损伤部位则与分解代谢过程的激活有关。
