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[创伤后动脉血氧张力值波动对肺挫伤大鼠肺、肝和心肌脂质过氧化强度的影响]

[Effect of posttraumatic fluctuations in the oxygen tension value in the arterial blood on the intensity of lipid peroxidation in the lungs, liver and myocardium of rats with a lung contusion].

作者信息

Kulitskaia V I, Murzin G V

出版信息

Biull Eksp Biol Med. 1984 Sep;98(9):276-8.

PMID:6487780
Abstract

It has been demonstrated in rat experiments that accumulation of lipid peroxidation products in the lungs, liver and myocardium in the early posttraumatic period of pulmonary contusion (the first week after trauma) is observed during the recovery of oxygen tension is the arterial blood (PaO2) rather than during the period of the appearance of arterial hypoxemia. In the lungs, accumulation of malonic dialdehyde (MDA) occurred together with PaO2 recovery in the myocardium and liver, MDA was recorded to accumulate in the initial period of PaO2 recovery, whereupon the MDA content in the myocardium dropped to the MDA content in the myocardium of intact rats, while that in the liver returned to normal only partially.

摘要

大鼠实验表明,肺挫伤创伤后早期(创伤后第一周),肺、肝和心肌中脂质过氧化产物的积累出现在动脉血氧分压(PaO2)恢复期间,而非动脉血氧不足出现期间。在肺中,丙二醛(MDA)的积累与心肌和肝脏中PaO2的恢复同时发生,MDA在PaO2恢复初期有记录显示其积累,随后心肌中的MDA含量降至完整大鼠心肌中的MDA含量水平,而肝脏中的MDA含量仅部分恢复正常。

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