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[肝脏缺血及复氧过程中的脂质过氧化与游离二价铁]

[Lipid peroxidation and free Fe2+ during ischemia and reoxygenation of the liver].

作者信息

Kozlov A V, Vdovin A V, Azizova O A, Vladimirov Iu A

出版信息

Biull Eksp Biol Med. 1987 Aug;104(8):165-7.

PMID:3620671
Abstract

Ischemia and reoxygenation were experimentally induced in thin liver sections. It has been shown that free iron decompartmentalization takes place 30 min after the induction of ischemia, with no lipid peroxidation activation observed. In reoxygenation, activation of lipid peroxidation and decrease in free iron concentration take place in the liver cells. It is suggested that free iron accumulation in the tissues during ischemia causes lipid peroxidation activation during reoxygenation.

摘要

在薄肝切片中通过实验诱导缺血和再氧合。结果表明,缺血诱导后30分钟发生游离铁的去分隔化,未观察到脂质过氧化激活。在再氧合过程中,肝细胞中发生脂质过氧化激活和游离铁浓度降低。提示缺血期间组织中游离铁的积累导致再氧合期间脂质过氧化激活。

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