收支平衡：核糖体大亚基生物发生的普遍驱动因素。

Making ends meet: a universal driver of large ribosomal subunit biogenesis.

机构信息

Department of Molecular Biology, University Medical Centre Göttingen, Göttingen, Germany.

Molecular, Cellular and Developmental Biology Unit, University of Toulouse, Toulouse, France.

出版信息

Trends Biochem Sci. 2023 Mar;48(3):213-215. doi: 10.1016/j.tibs.2022.09.003. Epub 2022 Oct 4.

DOI:10.1016/j.tibs.2022.09.003

PMID:36207216

Abstract

A common aspect of ribosome assembly, conserved across all domains of life, is the establishment of connections between the 5' and 3' ends of the large subunit (LSU) ribosomal RNA (rRNA) to initiate rRNA domain compaction and subunit assembly. We discuss the diverse mechanisms employed in different organisms to accomplish this important event.

摘要

核糖体组装的一个共同特征是，在所有生命领域中都保守的，是在大亚基（LSU）核糖体 RNA（rRNA）的 5' 和 3' 末端之间建立连接，以启动 rRNA 结构域的紧缩和亚基组装。我们讨论了不同生物体中用于完成这一重要事件的不同机制。