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SARS-COV-2 的神经系统并发症和感染机制。

Neurological complications and infection mechanism of SARS-COV-2.

机构信息

Laboratory of Aging Research and Cancer Drug Target, State Key Laboratory of Biotherapy, National Clinical Research Center for Geriatricts, West China Hospital, Sichuan University, No. 17, Block 3, Southern Renmin Road, 610041, Chengdu, Sichuan, PR China.

National Kunming High-level Biosafety Primate Research Center, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan, China.

出版信息

Signal Transduct Target Ther. 2021 Nov 23;6(1):406. doi: 10.1038/s41392-021-00818-7.

Abstract

Currently, SARS-CoV-2 has caused a global pandemic and threatened many lives. Although SARS-CoV-2 mainly causes respiratory diseases, growing data indicate that SARS-CoV-2 can also invade the central nervous system (CNS) and peripheral nervous system (PNS) causing multiple neurological diseases, such as encephalitis, encephalopathy, Guillain-Barré syndrome, meningitis, and skeletal muscular symptoms. Despite the increasing incidences of clinical neurological complications of SARS-CoV-2, the precise neuroinvasion mechanisms of SARS-CoV-2 have not been fully established. In this review, we primarily describe the clinical neurological complications associated with SARS-CoV-2 and discuss the potential mechanisms through which SARS-CoV-2 invades the brain based on the current evidence. Finally, we summarize the experimental models were used to study SARS-CoV-2 neuroinvasion. These data form the basis for studies on the significance of SARS-CoV-2 infection in the brain.

摘要

目前,SARS-CoV-2 已引发全球性大流行,威胁到许多人的生命。尽管 SARS-CoV-2 主要引起呼吸道疾病,但越来越多的数据表明,SARS-CoV-2 也可以入侵中枢神经系统(CNS)和周围神经系统(PNS),导致多种神经系统疾病,如脑炎、脑病、吉兰-巴雷综合征、脑膜炎和骨骼肌症状。尽管 SARS-CoV-2 的临床神经系统并发症的发生率不断增加,但 SARS-CoV-2 的精确神经入侵机制尚未完全确定。在这篇综述中,我们主要描述了与 SARS-CoV-2 相关的临床神经系统并发症,并根据现有证据讨论了 SARS-CoV-2 入侵大脑的潜在机制。最后,我们总结了用于研究 SARS-CoV-2 神经入侵的实验模型。这些数据为研究 SARS-CoV-2 感染大脑的意义奠定了基础。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41f4/8611063/f4b59f615d32/41392_2021_818_Fig1_HTML.jpg

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