Wei Yun, Li Xianxiao
Xiyuan Hospital of China Academy of Chinese Medical Sciences, 100091, Beijing, China.
Jingxi Cancer Hospital, 100161, Beijing, China.
Immun Ageing. 2022 Oct 8;19(1):44. doi: 10.1186/s12979-022-00300-0.
Microglia are immune-competent cells that are critically involved in maintaining normal brain function. A prominent characteristic of Alzheimer disease (AD) is microglial proliferation and activation concentrated around amyloid plaques in the brain. Recent research has revealed numerous microglial phenotypes related to aging and AD, apart from the traditional M1 and M2 types. Redox signalling modulates the acquisition of the classical or alternative microglia activation phenotypes. The numerous microglial functions can be achieved through these multiple phenotypes, which are associated with distinct molecular signatures.
小胶质细胞是具有免疫活性的细胞，在维持正常脑功能中起关键作用。阿尔茨海默病（AD）的一个突出特征是小胶质细胞增殖和激活集中在脑内的淀粉样斑块周围。除了传统的M1和M2类型外，最近的研究还揭示了许多与衰老和AD相关的小胶质细胞表型。氧化还原信号调节经典或替代性小胶质细胞激活表型的获得。这些多种表型可实现众多小胶质细胞功能，它们与不同的分子特征相关。
