Nelson R B, Friedman D P, O'Neill J B, Mishkin M, Routtenberg A
Brain Res. 1987 Jul 28;416(2):387-92. doi: 10.1016/0006-8993(87)90924-3.
Two protein kinase C (PKC) substrates of 50 and 81 kDa display topographical gradients in 32P-incorporation along the occipitotemporal visual processing pathway in rhesus monkey cerebral cortex. The 50 kDa protein appears to be homologous to protein F1 from rat (47 kDa) on the basis of isoelectric point, two-dimensional phosphopeptide maps, and kinase specificity, while the 81 kDa protein is probably the same as a previously described PKC substrate. The phosphorylation of protein F1 and 81 kDa was significantly higher in temporal regions of the occipitotemporal pathway, which have been implicated in the storage of visual representations, than in occipital regions, which appear to be less important for visual memory functions. These results suggest that the PKC phosphorylation system, which has been related previously to changes in neural plasticity, plays a progressively greater role in later stages of visual processing, and that this role may involve the storage of visual information in inferotemporal cortical areas.
在恒河猴大脑皮层枕颞视觉处理通路中，两种分子量分别为50 kDa和81 kDa的蛋白激酶C（PKC）底物在32P掺入方面呈现出拓扑梯度。基于等电点、二维磷酸肽图谱和激酶特异性，50 kDa的蛋白似乎与大鼠的F1蛋白（47 kDa）同源，而81 kDa的蛋白可能与先前描述的PKC底物相同。在枕颞通路的颞叶区域，F1蛋白和81 kDa蛋白的磷酸化水平显著高于枕叶区域，枕颞通路的颞叶区域与视觉表征的存储有关，而枕叶区域对视觉记忆功能似乎不太重要。这些结果表明，先前与神经可塑性变化相关的PKC磷酸化系统在视觉处理的后期阶段发挥着越来越重要的作用，并且这一作用可能涉及将视觉信息存储在颞下皮质区域。
