College of Food Science and Engineering, Northwest A&F University, Yangling, Shaanxi, China.
College of Food Science and Engineering, Northwest A&F University, Yangling, Shaanxi, China.
Adv Colloid Interface Sci. 2022 Nov;309:102781. doi: 10.1016/j.cis.2022.102781. Epub 2022 Sep 24.
Adequate intake of live probiotics can provide benefits to human health and wellbeing. However, free probiotics tend to lose their viability during the production, storage, and distribution of foods, as well as during their passage through the human gastrointestinal tract. A well-designed probiotic encapsulation system can enhance the viability of probiotics in foods and within the gastrointestinal tract, thereby ensuring more live bacteria reach the colon in an active form. This review summarizes the design of encapsulated probiotics and focuses on recent progress on the development of co-encapsulation systems containing mixed probiotics, mixtures of probiotics and prebiotics ("synbiotics"), or mixtures of probiotics and nutraceuticals ("nutrabiotics"). It then discusses the application of these co-encapsulation systems in functional foods, and highlights their potential benefits for human health, including regulating intestinal flora balance, safeguarding intestinal barrier integrity, maintaining immune homeostasis, and regulating blood glucose levels. Finally, challenges facing the large-scale commercialization of probiotic-loaded functional foods are discussed and suggestions for improving their performance are highlighted.
摄入足够的活菌益生菌可有益于人类健康和幸福。然而，在食品生产、储存和配送过程中，以及在通过人体胃肠道的过程中，自由益生菌往往会失去其生存能力。精心设计的益生菌包封系统可以增强食品和胃肠道内益生菌的生存能力，从而确保更多活菌以活性形式到达结肠。本文综述了包封益生菌的设计，并重点介绍了近年来关于包含混合益生菌、益生菌和益生元（“合生素”）或益生菌和营养保健品（“营养保健品”）混合物的共包封系统的开发进展。然后讨论了这些共包封系统在功能性食品中的应用，并强调了它们对人类健康的潜在益处，包括调节肠道菌群平衡、保护肠道屏障完整性、维持免疫内稳态和调节血糖水平。最后，讨论了益生菌负载型功能性食品大规模商业化所面临的挑战，并提出了改善其性能的建议。
