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杏仁核中部多巴胺能神经元:大鼠脑离散杏仁核核团中多巴胺周转的差异率

Mesoamygdaloid dopamine neurons: differential rates of dopamine turnover in discrete amygdaloid nuclei of the rat brain.

作者信息

Kilts C D, Anderson C M

出版信息

Brain Res. 1987 Jul 28;416(2):402-8. doi: 10.1016/0006-8993(87)90926-7.

DOI:10.1016/0006-8993(87)90926-7
PMID:3620969
Abstract

Populations of dopamine (DA) neurons innervating discrete amygdaloid nuclei exhibited a widely varying rate of biochemically estimated tonic activity, with DA turnover rates in the various amygdaloid nuclei increasing in the following order: central, medial posterior, medial, posterior, basal, basal posterior, cortical, lateral amygdaloid nucleus. With the exception of the central and the medially aligned amygdaloid nuclei, mesoamydaloid DA neurons exhibited a faster rate of DA turnover than the well-characterized DA neurons projecting to the caudate nucleus and olfactory tubercle. When amenable to estimation by this technique, the activity of mesoamygdaloid norepinephrine (NE)-containing neurons was less than that of mesoamygdaloid DA neurons. These findings support the focal influence of DA in the amygdaloid complex and reinforce the biochemical and functional heterogeneity of the component nuclei of the amygdala.

摘要

支配不同杏仁核核团的多巴胺(DA)神经元群体表现出生化估计的紧张性活动速率差异很大,各杏仁核核团中的DA周转率按以下顺序增加:中央核、内侧后核、内侧核、后核、基底核、基底后核、皮质核、外侧杏仁核。除中央核和内侧排列的杏仁核核团外,中杏仁核DA神经元的DA周转率比投射到尾状核和嗅结节的特征明确的DA神经元更快。当适用于该技术估计时,中杏仁核含去甲肾上腺素(NE)神经元的活性低于中杏仁核DA神经元。这些发现支持了DA在杏仁核复合体中的局部影响,并强化了杏仁核各组成核团的生化和功能异质性。

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引用本文的文献

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In vivo voltammetric measurement of evoked extracellular dopamine in the rat basolateral amygdaloid nucleus.
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Influence of acute and chronic haloperidol treatment on dopamine metabolism in the rat caudate-putamen, prefrontal cortex and amygdala.急性和慢性氟哌啶醇治疗对大鼠尾状核-壳核、前额叶皮质及杏仁核中多巴胺代谢的影响。
Psychopharmacology (Berl). 1991;104(2):194-200. doi: 10.1007/BF02244178.