Hagag Naglaa M, Hassan Ayah M, Zaher Mostafa R, Elnomrosy Sara M, Shemies Omayma A, Hussein Heba A, Ahmed Eman S, Ali Mohamed H, Ateay Mohamed, Abdel-Hakim Mahmoud A, Habashi Ahmed R, Eid Samah, El Zowalaty Mohamed E, Shahein Momtaz A
Genome Research Unit, Animal Health Research Institute, Agricultural Research Center, Giza 12618, Egypt.
Genome Research Unit, Animal Health Research Institute, Agricultural Research Center, Giza 12618, Egypt.
Virus Res. 2023 Jan 2;323:198960. doi: 10.1016/j.virusres.2022.198960. Epub 2022 Oct 6.
A newly emerging and exotic foot-and-mouth disease virus (FMDV) caused a recent outbreak of serotype A in Egypt in 2022, which affected cattle and water buffalo. Previous phylogenetic studies on FMDV circulating in Egypt have mainly focused on genomic regions encoding the structural proteins which determine FMDV serotype. No study has yet determined structural proteins sequences of the newly emerging Europe-South America (EURO-SA) lineage which was recently isolated from Egypt during a routine surveillance in 2022. The objective of the current study was to analyze the structural proteins of the Venezuelan type which belongs to EURO-SA. The new isolate was related to serotype A lineage Euro-South America. Phylogentic analyses have reveled that the newly isolated lineage samples were closely related to reported sequences that have been identified in Venzuela and Colombia. Analysis of structural protein sequences revealed the recent isolates belong to prototype strain A24 Cruzeiro. Notably, nucleotide sequences of the Egyptian isolate was related to Venezuelan, Brazilian, and Colombian strains with identity not exceeding 90%. The divergence which appears in the genetic identity of the Egyptian A/EURO-SA lineage from other related strains may be attributed to the absence of Euro-SA lineage sequence from Egypt. The present study is the first report on the detection of EURO-SA lineage in Egypt. The recent detection of the EURO-SA lineage samples may be explained due to imported animals from Colombia or Brazil which share geographical borders with Venezuela. The findings of the present study highlight the significance of continuous monitoring of FMDV in Egypt for newly emerging FMDVs.
一种新出现的外来口蹄疫病毒（FMDV）于2022年在埃及引发了最近的A型疫情，影响了牛和水牛。此前对在埃及流行的FMDV的系统发育研究主要集中在编码决定FMDV血清型的结构蛋白的基因组区域。尚未有研究确定2022年常规监测期间最近从埃及分离出的新兴欧洲-南美洲（EURO-SA）谱系的结构蛋白序列。本研究的目的是分析属于EURO-SA的委内瑞拉型的结构蛋白。新分离株与A型血清型欧洲-南美洲谱系有关。系统发育分析表明，新分离的谱系样本与在委内瑞拉和哥伦比亚鉴定出的已报道序列密切相关。结构蛋白序列分析表明，最近的分离株属于原型株A24 Cruzeiro。值得注意的是，埃及分离株的核苷酸序列与委内瑞拉、巴西和哥伦比亚的毒株相关，同一性不超过90%。埃及A/EURO-SA谱系与其他相关毒株在遗传同一性上出现的差异可能归因于埃及缺乏EURO-SA谱系序列。本研究是关于在埃及检测到EURO-SA谱系的首次报告。最近检测到EURO-SA谱系样本可能是由于从与委内瑞拉接壤的哥伦比亚或巴西进口动物所致。本研究结果凸显了在埃及持续监测FMDV以发现新出现的FMDV的重要性。
