Graivier Miles, Hill David, Katz Bruce, Boehm Kristin A, Fisher Juliya, Battista China
Aesthet Surg J Open Forum. 2022 Jun 29;4:ojac057. doi: 10.1093/asjof/ojac057. eCollection 2022.
Collagenase (CCH-aaes; QWO [Endo Aesthetics, Malvern, PA]) is an injectable, enzyme-based treatment indicated for the treatment of moderate to severe cellulite on the buttocks of adult women. The minimally invasive nature of the treatment makes it an attractive option for targeted disruption of the fibrous septae which give rise to the dimples characteristic of cellulite in buttocks and thighs.
The article provides an overview of cellulite treatment with CCH-aaes, including patient identification and education, treatment planning, CCH-aaes dilution, injection technique, safety, and early experience with mitigation of adverse events, including bruising.
As part of a continuing medical education (CME; xMedica, Alpharetta, GA) event on developments in cellulite treatment, a panel of experts developed a course and roundtable, which included lectures on cellulite physiology, new developments in the field of cellulite treatment, demonstrations of injection technique for CCH-aaes, and a review of considerations for the use of CCH-aaes in real-world clinical practice.
The practical guidance presented here is based upon real-world experience with CCH-aaes. The discussion includes strategies based on early experience for how to obtain the best results as well as suggestions on how to mitigate bruising.
CCH-aaes has been a welcome addition to the armamentarium for the treatment of cellulite. With knowledge of proper patient evaluation and injection technique, thorough patient education, diligent photography, and developing research on bruising mitigation, CCH-aaes shows great promise as an effective and safe modality for the management of cellulite.
胶原酶（CCH-aaes；QWO[Endo Aesthetics，马尔文，宾夕法尼亚州]）是一种可注射的、基于酶的治疗方法，适用于治疗成年女性臀部的中度至重度脂肪团。该治疗的微创性质使其成为一种有吸引力的选择，可用于有针对性地破坏纤维间隔，这些间隔导致臀部和大腿出现脂肪团特有的酒窝。
本文概述了使用CCH-aaes治疗脂肪团的方法，包括患者识别与教育、治疗规划、CCH-aaes稀释、注射技术、安全性以及减轻不良事件（包括瘀伤）的早期经验。
作为脂肪团治疗进展的继续医学教育（CME；xMedica，阿尔法利塔，佐治亚州）活动的一部分，一个专家小组开发了一门课程和一次圆桌会议，内容包括脂肪团生理学讲座、脂肪团治疗领域的新进展、CCH-aaes注射技术演示以及在实际临床实践中使用CCH-aaes的考虑因素回顾。
这里介绍的实用指南基于使用CCH-aaes的实际经验。讨论内容包括基于早期经验的如何获得最佳效果的策略以及如何减轻瘀伤的建议。
CCH-aaes已成为治疗脂肪团的有效手段。通过掌握正确的患者评估和注射技术、对患者进行全面教育、认真拍照以及开展减轻瘀伤的研究，CCH-aaes作为一种有效且安全的脂肪团管理方式显示出巨大潜力。
