Shridharani Sachin M, Kennedy MacKenzie L
Aesthet Surg J Open Forum. 2023 Feb 20;5:ojad014. doi: 10.1093/asjof/ojad014. eCollection 2023.
Collagenase clostridium histolyticum-aaes (CCH-aaes) is approved for the treatment of moderate-to-severe buttock cellulite in adult women.
To report on real-world experience with CCH-aaes in the treatment of buttock and thigh cellulite.
Retrospective analysis of medical records from a single treatment center.
The population comprised 28 consecutively treated women; mean age was 40.5 years (range, 23-56 years) and mean body mass index was 25.9 kg/m (range, 19.6-41.0 kg/m). Treatment areas were buttocks only (78.6% of patients), thighs only (10.7%), or both buttocks and thighs (10.7%). Most patients (89.3%) were treated in 2 areas (buttocks or thighs) at each visit; however, 3 patients were treated in 4 areas. At each session, the CCH-aaes dose was 0.07 mg per dimple (0.3 mL of 0.23 mg/mL for buttock cellulite; 1.5 mL of 0.046 mg/mL for thigh cellulite). The mean number of treatment sessions was 2.6 (range, 1-4) for buttock cellulite and 2.5 (range 1-3) for thigh cellulite. The mean number of dimples treated was 11.5 (range, 3-17) per buttock, 11.0 (range, 1-14) per thigh, and 23.4 (range, 8-32) overall per treatment session. Injection site-related adverse events of special interest were experienced by all 28 patients: bruising (100%), edema (96.4%), tenderness (85.7%), nodules (39.3%), pruritus (32.1%), and hyperpigmentation indicative of hemosiderin staining (7.1%). Mean duration of injection-site bruising was 8.8 days (range, 2-15 days).
CCH-aaes is an effective, well-tolerated, minimally invasive treatment option for buttock and thigh cellulite in women.
溶组织梭状芽孢杆菌胶原酶aaes（CCH-aaes）已被批准用于治疗成年女性的中度至重度臀部脂肪团。
报告CCH-aaes治疗臀部和大腿脂肪团的实际应用经验。
对单个治疗中心的病历进行回顾性分析。
研究对象为28例连续接受治疗的女性；平均年龄40.5岁（范围23 - 56岁），平均体重指数为25.9kg/m²（范围19.6 - 41.0kg/m²）。治疗部位仅为臀部（78.6%的患者）、仅为大腿（10.7%）或臀部和大腿均有（10.7%）。大多数患者（89.3%）每次就诊时在2个部位（臀部或大腿）接受治疗；然而，有3例患者在4个部位接受治疗。每次治疗时，CCH-aaes的剂量为每个酒窝0.07mg（臀部脂肪团用0.23mg/mL的溶液0.3mL；大腿脂肪团用0.046mg/mL的溶液1.5mL）。臀部脂肪团的平均治疗次数为2.6次（范围1 - 4次），大腿脂肪团为2.5次（范围1 - 3次）。每次治疗时，每个臀部平均治疗的酒窝数为11.5个（范围3 - 17个），每个大腿平均治疗的酒窝数为11.0个（范围1 - 14个），每次治疗总体平均治疗的酒窝数为23.4个（范围8 - 32个）。所有28例患者均出现了特别关注的注射部位相关不良事件：瘀斑（100%）、水肿（96.4%）、压痛（85.7%）、结节（39.3%）、瘙痒（32.1%）以及提示含铁血黄素沉着的色素沉着（7.1%）。注射部位瘀斑的平均持续时间为8.8天（范围2 - 15天）。
CCH-aaes是治疗女性臀部和大腿脂肪团的一种有效、耐受性良好的微创治疗选择。
