Erdem H, Canakci E, Kaya Y, Ozbilen M, Ankarali H
Ordu University, Department of Pathology, Ordu.
Ordu University, Department of Anesthesia and Reanimation, Ordu.
Acta Endocrinol (Buchar). 2022 Apr-Jun;18(2):156-163. doi: 10.4183/aeb.2022.156.
The aim of this study was to investigate the relationship of Claudin-5, Apelin, Tumor Necrosis Factor Alpha (TNF-α) expression, and body mass index (BMI) of cholecystectomies.
Sixty-eight paraffin embedded cholecystectomy specimens diagnosed as chronic cholecystitis were collected in the Pathology Department of the Training and Research Hospital between 2015-2017. The samples were stained with Apelin, Claudin-5 and TNF-α. The immunohistochemical study was carried out using the system in an automatic staining machine.
There was a significant positive correlation between BMI and TNF-α staining (p=0.010). This result indicated that the degree of staining increased together with BMI. When age, BMI, and the other biochemical parameters were evaluated, a significant correlation was found between BMI and blood glucose only (p=0.029); correlations of BMI with the other parameters were not statistically significant.
Although there is no relationship between inflammation and BMI with Claudin-5 and Apelin in this study, there is a significant relationship between BMI and TNF-α.
本研究旨在探讨胆囊切除术患者中Claudin-5、Apelin、肿瘤坏死因子α（TNF-α）表达与体重指数（BMI）之间的关系。
2015年至2017年期间，在培训与研究医院病理科收集了68例诊断为慢性胆囊炎的石蜡包埋胆囊切除标本。样本用Apelin、Claudin-5和TNF-α进行染色。使用自动染色机中的系统进行免疫组织化学研究。
BMI与TNF-α染色之间存在显著正相关（p = 0.010）。该结果表明染色程度随BMI升高。在评估年龄、BMI和其他生化参数时，仅发现BMI与血糖之间存在显著相关性（p = 0.029）；BMI与其他参数的相关性无统计学意义。
尽管本研究中炎症与BMI和Claudin-5及Apelin之间无关联，但BMI与TNF-α之间存在显著关系。
