Wang Bin, Zhu Chun-Rong, Liu Hong, Yao Xin-Min, Wu Jian
Center of Breast and Thyroid Surgery, Department of General Surgery, Chengdu Third People's Hospital, Chengdu, China.
Department of Oncology Ward 2, Chengdu Third People's Hospital, Chengdu, China.
Front Oncol. 2022 Sep 23;12:950047. doi: 10.3389/fonc.2022.950047. eCollection 2022.
We conducted a meta-analysis to study the relationship between pretracheal and/or prelaryngeal lymph node metastasis and paratracheal and lateral lymph node metastasis in papillary thyroid carcinoma.
A systematic literature search was conducted using PubMed, Embase, and the Cochrane Library electronic databases for studies published up to February 2022. The reference lists of retrieved articles were also reviewed. Two authors independently assessed the methodological quality and extracted the data. A random-effects model was used to calculate the overall pooled relative risk. Publication bias in these studies was evaluated using Egger's test and Begg's test.
Twenty-five independent studies involving 10,525 patients were included in the meta-analysis. The pooled relative risk for ipsilateral and contralateral paratracheal lymph node metastasis was 3.01 (95% confidence interval [CI]: 1.66, 5.45) and 5.68 (95% CI: 2.50, 12.88), respectively, in patients with pretracheal lymph node metastasis. Among patients with prelaryngeal lymph node metastasis, the pooled relative risk for ipsilateral paratracheal and/or pretracheal contralateral paratracheal, and lateral lymph node metastasis was 2.02 (95% CI: 1.90, 2.14), 2.22 (95% CI: 1.34, 3.67), and 3.85 (95% CI: 2.89, 5.14), respectively.
Pretracheal lymph node metastasis and prelaryngeal lymph node metastasis were significantly associated with an increased likelihood of both ipsilateral lymph node metastasis and contralateral paratracheal lymph node metastasis in papillary thyroid carcinoma. Prelaryngeal lymph node metastasis was positively correlated with the incidence of lateral lymph node metastasis.
我们进行了一项荟萃分析，以研究甲状腺乳头状癌气管前和/或喉前淋巴结转移与气管旁及侧方淋巴结转移之间的关系。
利用PubMed、Embase和Cochrane图书馆电子数据库对截至2022年2月发表的研究进行系统文献检索。还查阅了检索文章的参考文献列表。两位作者独立评估方法学质量并提取数据。采用随机效应模型计算总体合并相对风险。使用Egger检验和Begg检验评估这些研究中的发表偏倚。
荟萃分析纳入了25项涉及10525例患者的独立研究。气管前淋巴结转移患者同侧和对侧气管旁淋巴结转移的合并相对风险分别为3.01（95%置信区间[CI]：1.66，5.45）和5.68（95%CI：2.50，12.88）。在喉前淋巴结转移患者中，同侧气管旁和/或气管前对侧气管旁及侧方淋巴结转移 的合并相对风险分别为2.02（95%CI：1.90，2.14）、2.22（95%CI：1.34，3.67）和3.85（95%CI：2.89，5.14）。
甲状腺乳头状癌中，气管前淋巴结转移和喉前淋巴结转移与同侧淋巴结转移及对侧气管旁淋巴结转移可能性增加显著相关。喉前淋巴结转移与侧方淋巴结转移发生率呈正相关。
