Zhou Yueyuan, Xiao Zhongdang, Zhu Wei
Department of Clinical Medical Engineering, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing, China.
Front Oncol. 2022 Sep 23;12:998964. doi: 10.3389/fonc.2022.998964. eCollection 2022.
Triple-negative breast cancer (TNBC) is a particularly aggressive and invasive breast cancer subtype and is associated with poor clinical outcomes. Treatment approaches for TNBC remain limited partly due to the lack of expression of well-known molecular targets. Small extracellular vesicles (sEVs) carrying a variety of bioactive contents play an important role in intercellular communications. The biomolecules including nucleic acids, proteins, and metabolites can be transferred locally or systematically to recipient cells and regulate their biological states and are involved in physiological and pathological processes. Recently, despite the extensive attraction to the physiological functions of sEVs, few studies focus on the roles of sEVs in TNBC. In this review, we will summarize the involvement of sEVs in the tumor microenvironment of TNBC. Moreover, we will discuss the potential roles of sEVs as diagnostic markers and treatment therapy in this heterogeneous breast cancer subtype. We finally summarize the clinical application of sEVs in TNBC.
三阴性乳腺癌（TNBC）是一种特别具有侵袭性的乳腺癌亚型，与较差的临床预后相关。TNBC的治疗方法仍然有限，部分原因是缺乏已知分子靶点的表达。携带多种生物活性成分的小细胞外囊泡（sEVs）在细胞间通讯中发挥着重要作用。包括核酸、蛋白质和代谢产物在内的生物分子可以局部或系统地转移到受体细胞，并调节其生物学状态，参与生理和病理过程。最近，尽管sEVs的生理功能受到广泛关注，但很少有研究关注sEVs在TNBC中的作用。在这篇综述中，我们将总结sEVs在TNBC肿瘤微环境中的参与情况。此外，我们将讨论sEVs作为这种异质性乳腺癌亚型的诊断标志物和治疗方法的潜在作用。我们最后总结了sEVs在TNBC中的临床应用。
