Department of General Surgery, Huangyan Hospital, Wenzhou Medical University, Taizhou, Zhejiang, China.
Department of Ultrasound, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.
Front Endocrinol (Lausanne). 2023 Jul 17;14:1202493. doi: 10.3389/fendo.2023.1202493. eCollection 2023.
Breast cancer is one of the leading causes of cancer-related death in women. Currently, the treatment of breast cancer is limited by the lack of effectively targeted therapy and patients often suffer from higher severity, metastasis, and resistance. Extracellular vesicles (EVs) consist of lipid bilayers that encapsulate a complex cargo, including proteins, nucleic acids, and metabolites. These bioactive cargoes have been found to play crucial roles in breast cancer initiation and progression. Moreover, EV cargoes play pivotal roles in converting mammary cells to carcinogenic cells and metastatic foci by extensively inducing proliferation, angiogenesis, pre-metastatic niche formation, migration, and chemoresistance. The present update review mainly discusses EVs cargoes released from breast cancer cells and tumor-derived EVs in the breast cancer microenvironment, focusing on proliferation, metastasis, chemoresistance, and their clinical potential as effective biomarkers.
乳腺癌是导致女性癌症相关死亡的主要原因之一。目前，乳腺癌的治疗受到缺乏有效靶向治疗的限制，患者往往面临更高的严重程度、转移和耐药性。细胞外囊泡 (EVs) 由脂质双层组成，其中包含复杂的货物，包括蛋白质、核酸和代谢物。这些生物活性货物在乳腺癌的发生和发展中起着至关重要的作用。此外，EV 货物通过广泛诱导增殖、血管生成、前转移龛形成、迁移和化学抗性，在将乳腺细胞转化为致癌细胞和转移灶方面发挥着关键作用。本综述主要讨论了乳腺癌细胞和肿瘤衍生的 EVs 在乳腺癌微环境中释放的 EV 货物，重点讨论了增殖、转移、化学抗性及其作为有效生物标志物的临床潜力。
