人羊膜用于外阴癌根治性手术后肌皮裂开：一例报告。

Human amniotic membrane for myocutaneous dehiscence after a radical surgical treatment of vulvar cancer: A case report.

作者信息

Restaino Stefano, Paparcura Federico, Giorgiutti Cristina, Trojan Diletta, Montagner Giulia, Pengo Giancarlo, Pividore Grazia, Albanese Roberta, Rampino Emanuele, Dogareschi Teresa, Bove Tiziana, Titone Francesca, Trovò Marco, Garganese Giorgia, Parodi Pier Camillo, Scambia Giovanni, Driul Lorenza, Vizzielli Giuseppe

机构信息

Department of Maternal and Child Health, Obstetrics and Gynecology Clinic, University Hospital of Udine, Udine, Italy.

Medical Area Department (Dipartimento di Area Medica, DAME), Università degli Studi di Udine, Udine, Italy.

出版信息

Front Oncol. 2022 Sep 23;12:1009884. doi: 10.3389/fonc.2022.1009884. eCollection 2022.

DOI:10.3389/fonc.2022.1009884

PMID:36212440

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9539543/

Abstract

BACKGROUND

The application of the amniotic membrane could have a favourable effect on tissue repair and regeneration. We report the first case of implant of an amniotic membrane in a patient affected by myo-cutaneous dehiscence, after a radical surgical treatment for vulvar cancer.

METHODS

We describe a case of a 74-years-old patient affected by vulvar cancer. After radiotherapy, the patient underwent to an anterior pelvic exenteration with uretero-ileo-cutaneostomy by Wallace, bilateral pelvic lymphadenectomy, omental biopsies, omental flap, bilateral inguinal lymphadenectomy, resection of ulcerated left inguinal lesion, reconstruction with left gracilis muscle flap and locoregional V-Y advancement flap. The patient developed a myo-cutaneous dehiscence. Two months after the surgery, following an accurate curettage of the wound and negative pressure therapy, a patch of human amniotic membrane was implanted.

RESULTS

The surgical procedure was easy, feasible and did not require long operating room times. No intraoperative or postoperative complications occurred. The results obtained were encouraging with a marked improvement in the surgical wound.

CONCLUSION

the use of amniotic membranes was safely and easily performed to promote the healing of complicated surgical wounds.

摘要

背景

羊膜的应用可能对组织修复和再生产生有利影响。我们报告了首例在一名因外阴癌接受根治性手术治疗后发生肌皮裂开的患者中植入羊膜的病例。

方法

我们描述了一名74岁外阴癌患者的病例。放疗后，患者接受了Wallace输尿管回肠皮肤造口术的前盆腔脏器清除术、双侧盆腔淋巴结清扫术、网膜活检、网膜瓣、双侧腹股沟淋巴结清扫术、切除溃疡的左侧腹股沟病变、用左侧股薄肌瓣重建以及局部V-Y推进瓣。患者出现了肌皮裂开。手术后两个月，在对伤口进行精确刮除和负压治疗后，植入了一片人羊膜。