增加哥伦比亚人群癌前胃部病变风险的毒力基因。

Virulence Genes of Increase the Risk of Premalignant Gastric Lesions in a Colombian Population.

机构信息

Interdisciplinary Research Group on Health and Disease, Cooperative University of Colombia, Pasto, Colombia.

Human and Applied Genetics Research Group, University of Cauca, Popayán, Colombia.

出版信息

Can J Gastroenterol Hepatol. 2022 Sep 28;2022:7058945. doi: 10.1155/2022/7058945. eCollection 2022.

DOI:10.1155/2022/7058945

PMID:36212919

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9534724/

Abstract

BACKGROUND

Genetic variability of is associated with various gastrointestinal diseases; however, little is known about interaction with sociodemographic in the development of premalignant lesions in Colombian patients.

METHODS

An analytical study was conducted including cases (patients with gastric atrophy, intestinal metaplasia, and gastric dysplasia) and controls (patients with nonatrophic gastritis). Sociodemographic information was obtained using a questionnaire. Histopathological diagnosis was performed according to the Sydney System. The cagA and vacA genotypes were established using polymerase chain reaction in paraffin blocks. The effect of each variable on the study outcome (premalignant lesion) is presented as odds ratio (OR) and 95% CI. A value of <0.05 was considered as statistically significant.

RESULTS

The vacA/s1m1 genotype increases the risk of developing premalignant lesions of the stomach (OR: 3.05, 95% IC: 1.57-5.91, =0.001). Age and educational level showed a positive interaction with the s1m1 genotype (adjusted OR: 3.68, 95% CI: 1.73-7.82, =0.001). The cagA genotype was not correlated to the development of premalignant lesions of the stomach (OR: 1.32, 95% CI: 0.90-1.94, =0.151).

CONCLUSIONS

The vacA genotype, age, and educational level are indicators of the risk of developing premalignant lesions of the stomach in the study population. . Genetic variability of and sociodemographic information could be used to predict the risk of premalignant lesions in stomach in Colombian population.

摘要

背景

基因变异与各种胃肠道疾病有关；然而，关于其与社会人口统计学因素在哥伦比亚患者癌前病变发展中的相互作用知之甚少。

方法

进行了一项分析性研究，包括病例（胃萎缩、肠化生和胃发育不良患者）和对照（非萎缩性胃炎患者）。使用问卷获得社会人口统计学信息。根据悉尼系统进行组织病理学诊断。使用聚合酶链反应在石蜡块中建立 cagA 和 vacA 基因型。每个变量对研究结果（癌前病变）的影响以比值比（OR）和 95%置信区间（CI）表示。值<0.05 被认为具有统计学意义。

结果

vacA/s1m1 基因型增加了发生胃部癌前病变的风险（OR：3.05，95%CI：1.57-5.91， =0.001）。年龄和教育水平与 s1m1 基因型呈正交互作用（调整后的 OR：3.68，95%CI：1.73-7.82， =0.001）。cagA 基因型与胃癌前病变的发生无关（OR：1.32，95%CI：0.90-1.94， =0.151）。