Wang Lei, Wu Hongxia, Wang Rongrong, Zhang Hongyan, Chen Jie
Department of Oncology, Chengyang District Peoples's Hospital, Qingdao, Shandong 266100, China.
Evid Based Complement Alternat Med. 2022 Sep 28;2022:6202457. doi: 10.1155/2022/6202457. eCollection 2022.
To explore the risk factors that affect long-term presacral tumour recurrence in patients with rectal cancer (RC) after radical rectal cancer resection.
In our study, a total of 50 patients with presacral tumour recurrence after radical resection of RC in our hospital between May 2017 and May 2018 were enrolled in the observation group, and the other 50 patients without presacral tumour recurrence after the resection over the same span were enrolled in the control group. The two groups were compared in distant metastatic rate and long-term recurrence, and corresponding K-M curves were drawn. Additionally, the quality of life of the two groups was also compared. Patients in both groups were assigned to a long-term recurrence group or a non-long-term recurrence group based on their long-term recurrence, and a multivariate logistic regression analysis was carried out for analysis of risk factors of long-term recurrence.
The two groups were not greatly different in clinical data ( > 0.05). The observation group was higher than the control group in terms of distant metastasis and long-term recurrence ( < 0.05). In addition, the MOS 36-Item Short-Form Health Survey (SF-36) scores of the observation group were all lower than those of the control group in the eight dimensions ( < 0.05). Moreover, tumour diameter (OR: 0.315, 95% CI: 0.118-0.835), differentiation (OR: 2.652, 95% CI: 1.086-6.852), and presacral recurrence (OR: 2.370, 95% CI: 1.263-4.447) were all independent risk factors for long-term recurrence of patients undergoing radical resection of RC.
Patients undergoing radical resection of RC face greatly higher risks of presacral tumour distant metastasis and long-term tumour recurrence, and tumour diameter ≥ 5 cm, low-differentiation degree, and presacral recurrence are independent risk factors for long-term recurrence of patients undergoing radical resection of RC. In the future, when performing radical resection of rectal cancer, it is necessary to pay attention to the changes in the above indicators in patients so as to prevent tumour recurrence.
探讨影响直肠癌（RC）根治性切除术后骶前肿瘤长期复发的危险因素。
本研究选取2017年5月至2018年5月在我院接受RC根治性切除术后发生骶前肿瘤复发的50例患者作为观察组，同期选取50例未发生骶前肿瘤复发的患者作为对照组。比较两组的远处转移率和长期复发情况，并绘制相应的K-M曲线。此外，还比较了两组的生活质量。根据长期复发情况将两组患者分为长期复发组和非长期复发组，并进行多因素logistic回归分析以分析长期复发的危险因素。
两组临床资料差异无统计学意义（>0.05）。观察组远处转移和长期复发率高于对照组（<0.05）。此外，观察组的医学结局研究简明健康调查量表（SF-36）在八个维度上的得分均低于对照组（<0.05）。而且，肿瘤直径（OR：0.315，95%CI：0.118-0.835）、分化程度（OR：2.652，95%CI：1.086-6.852）和骶前复发（OR：2.370，95%CI：1.263-4.447）均为RC根治性切除患者长期复发的独立危险因素。
RC根治性切除患者面临骶前肿瘤远处转移和肿瘤长期复发的风险更高，肿瘤直径≥5 cm、低分化程度和骶前复发是RC根治性切除患者长期复发的独立危险因素。今后在进行直肠癌根治性切除时，有必要关注患者上述指标的变化，以预防肿瘤复发。
