Khaled Shimaa S, Soliman Hanan A, Abdel-Gabbar Mohammed, Ahmed Noha A, Attia Kandil Abdel Hai Ali, Mahran Hesham A, El-Nahass El-Shaymaa, Ahmed Osama M
Biochemistry Department, Faculty of Science, Beni-Suef University, P.O. Box 62521, Beni-Suef, Egypt.
Physiology Division, Zoology Department, Faculty of Science, Beni-Suef University, P.O. Box 62521, Beni-Suef, Egypt.
Evid Based Complement Alternat Med. 2022 Sep 30;2022:8739815. doi: 10.1155/2022/8739815. eCollection 2022.
This study assessed the preventive properties of naringin and naringenin on paclitaxel-induced nephrotoxicity and cardiotoxicity in adult male Wistar rats. Intraperitoneal injection of paclitaxel 2 mg/kg body weight, two days/week on the 2nd and 5th days of each week, with or without oral administration of naringin and/or naringenin 10 mg/kg body weight every other day, was continued for six weeks. Treatment of rats with naringin and/or naringenin significantly reversed elevated serum creatinine, urea, and uric acid levels caused by paclitaxel, reflecting improved kidney function. Similarly, heart dysfunction induced by paclitaxel was alleviated after treatment with naringin and/or naringenin, as evidenced by significant decreases in elevated CK-MB and LDH activities. After drug administration, histopathological findings and lesion scores in the kidneys and heart were markedly decreased by naringin and/or naringenin. Moreover, the treatments reversed renal and cardiac lipid peroxidation and the negative impacts on antioxidant defenses via raising GSH, SOD, and GPx. The preventive effects of naringin and naringenin were associated with suppressing oxidative stress and reestablishing antioxidant defenses. A combination of naringin and naringenin was the most efficacious in rescuing organ function and structure.
本研究评估了柚皮苷和柚皮素对成年雄性Wistar大鼠紫杉醇诱导的肾毒性和心脏毒性的预防作用。腹腔注射2mg/kg体重的紫杉醇，每周第2天和第5天给药，每周2次，连续6周，同时每隔一天口服10mg/kg体重的柚皮苷和/或柚皮素，或不进行该处理。用柚皮苷和/或柚皮素处理大鼠可显著逆转紫杉醇引起的血清肌酐、尿素和尿酸水平升高，这反映了肾功能的改善。同样，用柚皮苷和/或柚皮素处理后，紫杉醇诱导的心脏功能障碍得到缓解，这表现为升高的肌酸激酶同工酶（CK-MB）和乳酸脱氢酶（LDH）活性显著降低。给药后，柚皮苷和/或柚皮素可使肾脏和心脏的组织病理学检查结果及损伤评分显著降低。此外，这些处理通过提高谷胱甘肽（GSH）、超氧化物歧化酶（SOD）和谷胱甘肽过氧化物酶（GPx），逆转了肾脏和心脏的脂质过氧化以及对抗氧化防御的负面影响。柚皮苷和柚皮素的预防作用与抑制氧化应激和重建抗氧化防御有关。柚皮苷和柚皮素联合使用在挽救器官功能和结构方面最为有效。
