Yang Jie, Zeng Huiying, Luo Yusheng, Chen Ying, Wang Miao, Wu Chuanbin, Hu Ping
Department of Burns & Plastic Surgery, Guangzhou Red Cross Hospital, Faculty of Medical Science, Jinan University, Guangzhou 510006, China.
College of Pharmacy, Jinan University, Guangzhou 510006, China.
Polymers (Basel). 2024 Sep 14;16(18):2606. doi: 10.3390/polym16182606.
Poly(lactic-co-glycolic acid) (PLGA) is a widely used biodegradable and biocompatible copolymer in drug delivery systems (DDSs). In this article, we highlight the critical physicochemical properties of PLGA, including its molecular weight, intrinsic viscosity, monomer ratio, blockiness, and end caps, that significantly influence drug release profiles and degradation times. This review also covers the extensive literature on the application of PLGA in delivering small-molecule drugs, proteins, peptides, antibiotics, and antiviral drugs. Furthermore, we discuss the role of PLGA-based DDSs in the treating various diseases, including cancer, neurological disorders, pain, and inflammation. The incorporation of drugs into PLGA nanoparticles and microspheres has been shown to enhance their therapeutic efficacy, reduce toxicity, and improve patient compliance. Overall, PLGA-based DDSs holds great promise for the advancement of the treatment and management of multiple chronic conditions.
聚乳酸-乙醇酸共聚物（PLGA）是药物递送系统（DDS）中广泛使用的可生物降解且生物相容的共聚物。在本文中，我们强调了PLGA的关键物理化学性质，包括其分子量、特性粘度、单体比例、嵌段性和端基，这些性质会显著影响药物释放曲线和降解时间。本综述还涵盖了关于PLGA在递送小分子药物、蛋白质、肽、抗生素和抗病毒药物方面应用的大量文献。此外，我们讨论了基于PLGA的DDS在治疗各种疾病（包括癌症、神经疾病、疼痛和炎症）中的作用。已证明将药物掺入PLGA纳米颗粒和微球中可提高其治疗效果、降低毒性并改善患者顺应性。总体而言，基于PLGA的DDS在推进多种慢性病的治疗和管理方面具有巨大潜力。
