Katsumata Ryo, Manabe Noriaki, Monobe Yasumasa, Tanikawa Tomohiro, Ayaki Maki, Suehiro Mitsuhiko, Fujita Minoru, Kamada Tomoari, Haruma Ken, Kawamoto Hirofumi
Department of General Internal Medicine 2, Kawasaki Medical School General Medical Center, 2-6-1 Nakasange, Kita-ku, Okayama 700-8505, Japan.
Division of Endoscopy and Ultrasonography, Kawasaki Medical School General Medical Center, 2-6-1 Nakasange, Kita-ku, Okayama 700-8505, Japan.
J Clin Biochem Nutr. 2022 Sep;71(2):165-171. doi: 10.3164/jcbn.22-19. Epub 2022 Aug 10.
The severity and distribution of melanosis coli differ among individuals, and the related factors remain unknown. Additionally, their clinical implications have not been sufficiently demon-strated. Thus, we aimed to detect clinical factors related to the severity and range of melanosis coli and elucidate the associations between the grade, location, and detection rate of colorectal neoplasms. Colonoscopy cases performed at our institution from January 2011 to February 2021 were included. Melanosis coli was classified into mild and severe grades. Clinical characteristics and neoplasm detection rates were compared between the mild and severe MC groups and between the right-sided and whole-colon melanosis coli groups. Overall, 236 MC (mild, = 143; severe, = 93) cases, of which 50 were right-sided, 5 were left-sided, and 181 were whole-colon melanosis coli cases, were enrolled. The proportion of anthranoid users was higher in the severe melanosis coli group than in the mild melanosis coli group. The adenoma detection rate was higher in the severe melanosis coli and whole-colon melanosis coli groups. The prevalence of neoplasms measuring 5-9 mm and >9 mm was higher in the severe melanosis coli group (<0.01 and = 0.04). Severe melanosis coli due to anthranoid usage is associated with colorectal adenoma development.
结肠黑变病的严重程度和分布因人而异，相关因素尚不清楚。此外，其临床意义尚未得到充分证实。因此，我们旨在检测与结肠黑变病严重程度和范围相关的临床因素，并阐明结直肠肿瘤的分级、位置与检出率之间的关联。纳入了2011年1月至2021年2月在我院进行的结肠镜检查病例。结肠黑变病分为轻度和重度。比较了轻度和重度结肠黑变病组之间以及右侧和全结肠结肠黑变病组之间的临床特征和肿瘤检出率。总共纳入了236例结肠黑变病病例（轻度，=143例；重度，=93例），其中右侧结肠黑变病50例，左侧结肠黑变病5例，全结肠结肠黑变病181例。重度结肠黑变病组中蒽醌类药物使用者的比例高于轻度结肠黑变病组。重度结肠黑变病组和全结肠结肠黑变病组的腺瘤检出率较高。重度结肠黑变病组中直径5 - 9毫米和>9毫米肿瘤的患病率较高（<0.01和=0.04）。因使用蒽醌类药物导致的重度结肠黑变病与结直肠腺瘤的发生有关。
