Nusko G, Schneider B, Müller G, Kusche J, Hahn E G
Department of Medicine I, University of Erlangen-Nürnberg, FRG.
Pharmacology. 1993 Oct;47 Suppl 1:234-41. doi: 10.1159/000139863.
In a retrospective study a cohort of 2,277 patients was defined by colonoscopy. Among other factors it was tested whether in these patients laxative use or the endoscopically diagnosed presence of melanosis coli were risk factors related to colorectal neoplasma. In comparison to patients taking no laxatives there was no significant increase in colorectal cancer rate either in laxative users or in patients with melanosis coli. However, there was a statistically significant association between the occurrence of colorectal adenomas and laxative use (relative risk of all patients exposed to laxatives = 1.72; of patients exposed to laxatives without melanosis coli = 1.47). The relative risk of adenoma development in patients with melanosis coli was 2.19. Taking into account that polyps can be diagnosed in the dark mucosa of melanosis coli patients more easily, even this relative risk of 2.19 seems to be related to a generally enhanced risk of laxative intake rather than to a special group of (anthranoid containing) laxatives.
在一项回顾性研究中，通过结肠镜检查确定了2277名患者组成的队列。除其他因素外，还检测了这些患者使用泻药或内镜诊断出的结肠黑变病是否为与结直肠肿瘤相关的危险因素。与未使用泻药的患者相比，泻药使用者或结肠黑变病患者的结直肠癌发生率均未显著增加。然而，结直肠腺瘤的发生与使用泻药之间存在统计学上的显著关联（所有暴露于泻药的患者的相对风险 = 1.72；暴露于泻药但无结肠黑变病的患者的相对风险 = 1.47）。结肠黑变病患者发生腺瘤的相对风险为2.19。考虑到在结肠黑变病患者的深色黏膜中更容易诊断出息肉，即使这种2.19的相对风险似乎也与泻药摄入普遍增加的风险有关，而不是与特定的（含蒽类）泻药有关。
